Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase
AbstractThere are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper, the synthesis of pelorol has been completed, and the synthesis of some intermediates has been optimized and scaled up. Five pelorol analogs have also been prepared. Preliminary biological activity testing demonstrated that compounds 5 and 6 might be potential lead compounds for cancer therapy. View Full-Text
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Luo, Y.; Chen, H.; Weng, J.; Lu, G. Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase. Mar. Drugs 2016, 14, 118.
Luo Y, Chen H, Weng J, Lu G. Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase. Marine Drugs. 2016; 14(6):118.Chicago/Turabian Style
Luo, Yongjie; Chen, Huixuan; Weng, Jiang; Lu, Gui. 2016. "Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase." Mar. Drugs 14, no. 6: 118.
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