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Mar. Drugs 2016, 14(6), 118; doi:10.3390/md14060118

Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase

1
Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
Institute of Human Virology, Sun Yat-sen University, Guangzhou 510080, China
*
Author to whom correspondence should be addressed.
Academic Editor: Patrizia Diana
Received: 16 April 2016 / Revised: 13 May 2016 / Accepted: 18 May 2016 / Published: 21 June 2016
(This article belongs to the Special Issue Synthesis of Antitumor Marine Alkaloids and Related Analogues)
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Abstract

There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper, the synthesis of pelorol has been completed, and the synthesis of some intermediates has been optimized and scaled up. Five pelorol analogs have also been prepared. Preliminary biological activity testing demonstrated that compounds 5 and 6 might be potential lead compounds for cancer therapy. View Full-Text
Keywords: marine organisms; pelorol; total synthesis; PI3K inhibitor; anti-tumor activity marine organisms; pelorol; total synthesis; PI3K inhibitor; anti-tumor activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Luo, Y.; Chen, H.; Weng, J.; Lu, G. Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase. Mar. Drugs 2016, 14, 118.

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