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Mar. Drugs 2016, 14(6), 117; doi:10.3390/md14060117

Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata

1
The NeaNat Group, Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
2
Department of Surgical and Biomedical Sciences, Faculty of Medicine, University of Perugia, Via Gambuli 1, S. Andrea delle Fratte, Perugia 06132, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 28 April 2016 / Revised: 31 May 2016 / Accepted: 2 June 2016 / Published: 18 June 2016
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Abstract

A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the pregnane X receptor (PXR) activity of phallusiasterol C has been investigated; although the new sterol resulted inactive, this study adds more items to the knowledge of the structure-PXR regulating activity relationships in the case of sulfated steroids. View Full-Text
Keywords: sulfated sterol; tunicates; Phallusia fumigata; structure elucidation; nuclear receptors; PXR modulator sulfated sterol; tunicates; Phallusia fumigata; structure elucidation; nuclear receptors; PXR modulator
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MDPI and ACS Style

Imperatore, C.; Senese, M.; Aiello, A.; Luciano, P.; Fiorucci, S.; D’Amore, C.; Carino, A.; Menna, M. Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata. Mar. Drugs 2016, 14, 117.

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