Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs
AbstractNew thiazole nortopsentin analogs in which one of the two indole units was replaced by a naphthyl and/or 7-azaindolyl portion, were conveniently synthesized. Among these, three derivatives showed good antiproliferative activity, in particular against MCF7 cell line, with GI50 values in the micromolar range. Their cytotoxic effect on MCF7 cells was further investigated in order to elucidate their mode of action. Results showed that the three compounds act as pro-apoptotic agents inducing a clear shift of viable cells towards early apoptosis, while not exerting necrotic effects. They also caused cell cycle perturbation with significant decrease in the percentage of cells in the G0/G1 and S phases, accompanied by a concomitant percentage increase of cells in the G2/M phase, and appearance of a subG1-cell population. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Spanò, V.; Attanzio, A.; Cascioferro, S.; Carbone, A.; Montalbano, A.; Barraja, P.; Tesoriere, L.; Cirrincione, G.; Diana, P.; Parrino, B. Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs. Mar. Drugs 2016, 14, 226.
Spanò V, Attanzio A, Cascioferro S, Carbone A, Montalbano A, Barraja P, Tesoriere L, Cirrincione G, Diana P, Parrino B. Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs. Marine Drugs. 2016; 14(12):226.Chicago/Turabian Style
Spanò, Virginia; Attanzio, Alessandro; Cascioferro, Stella; Carbone, Anna; Montalbano, Alessandra; Barraja, Paola; Tesoriere, Luisa; Cirrincione, Girolamo; Diana, Patrizia; Parrino, Barbara. 2016. "Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs." Mar. Drugs 14, no. 12: 226.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.