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Mar. Drugs 2015, 13(1), 237-248; doi:10.3390/md13010237

New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

1
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
3
Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China
These authors contributed equally to this paper.
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 26 August 2014 / Accepted: 22 December 2014 / Published: 7 January 2015
(This article belongs to the Special Issue Terpenoids of Marine Origin)
View Full-Text   |   Download PDF [603 KB, uploaded 24 February 2015]   |  

Abstract

Four new meroterpenoids (25), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 17 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities. View Full-Text
Keywords: meroterpenoid; Aspergillus flavipes; endophytic fungus meroterpenoid; Aspergillus flavipes; endophytic fungus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bai, Z.-Q.; Lin, X.; Wang, J.; Zhou, X.; Liu, J.; Yang, B.; Yang, X.; Liao, S.; Wang, L.; Liu, Y. New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius. Mar. Drugs 2015, 13, 237-248.

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