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Mar. Drugs 2015, 13(2), 879-902; doi:10.3390/md13020879

New Insights on the Terpenome of the Red Seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta)

1
Institute of Biology, Federal University of Rio de Janeiro (UFRJ) Av. Carlos Chagas Filho, 373-CCS-IB-BLOCO A (ANEXO) A3-202, SAGE-COPPE, Rio de Janeiro 21941-599, Brazil
2
Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Campus Duque de Caxias, Avenida República do Paraguai, 120, Sarapuí, Duque de Caxias 25050-100, Brazil
3
Research Institute of the Botanical Garden of Rio de Janeiro, Rua Pacheco Leão, 915, Jardim Botânico, Rio de Janeiro 22460-030, Brazil
4
Departament of Marine Biology, Federal Fluminense University (UFF), Morro do Valonguinho, s/n, Centro, Niterói 24001-970, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: RuAngelie Edrada-Ebel
Received: 14 September 2014 / Revised: 17 December 2014 / Accepted: 12 January 2015 / Published: 10 February 2015
(This article belongs to the Special Issue Terpenoids of Marine Origin)
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Abstract

The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of these compounds is still very limited. We detected 20 different genes involved in the biosynthesis of terpenoid precursors, and 21 different genes coding for terpene synthases that are responsible for the chemical modifications of the terpenoid precursors, resulting in a high diversity of carbon chemical skeletons. In addition, we demonstrate through molecular and cytochemical approaches the occurrence of the mevalonate pathway involved in the biosynthesis of terpenes in L. dendroidea. This is the first report on terpene synthase genes in seaweeds, enabling further studies on possible heterologous biosynthesis of terpenes from L. dendroidea exhibiting ecological or biotechnological interest. View Full-Text
Keywords: seaweed; terpene synthase; prenyl transferase; gene; secondary metabolite; metabolic pathway; mevalonate pathway; transcriptome; Laurencia seaweed; terpene synthase; prenyl transferase; gene; secondary metabolite; metabolic pathway; mevalonate pathway; transcriptome; Laurencia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Oliveira, L.S.; Tschoeke, D.A.; de Oliveira, A.S.; Hill, L.J.; Paradas, W.C.; Salgado, L.T.; Thompson, C.C.; Pereira, R.C.; Thompson, F.L. New Insights on the Terpenome of the Red Seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). Mar. Drugs 2015, 13, 879-902.

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