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Pharmaceuticals 2015, 8(3), 366-415; doi:10.3390/ph8030366

Peptides and Peptidomimetics for Antimicrobial Drug Design

Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, Postboks 260, Roskilde 4000, Denmark
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Author to whom correspondence should be addressed.
Academic Editor: Guangshun Wang
Received: 26 March 2015 / Revised: 27 May 2015 / Accepted: 17 June 2015 / Published: 13 July 2015
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Abstract

The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics. View Full-Text
Keywords: antimicrobial peptides; mechanism of action; peptidomimetics antimicrobial peptides; mechanism of action; peptidomimetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mojsoska, B.; Jenssen, H. Peptides and Peptidomimetics for Antimicrobial Drug Design. Pharmaceuticals 2015, 8, 366-415.

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