Next Article in Journal
Condensation of Plasmid DNA Enhances Mitochondrial Association in Skeletal Muscle Following Hydrodynamic Limb Vein Injection
Next Article in Special Issue
Peptides and Peptidomimetics for Antimicrobial Drug Design
Previous Article in Journal
Pain Management in Ambulatory Surgery—A Review
Previous Article in Special Issue
Antimicrobial Peptides in Reptiles
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2014, 7(8), 866-880; doi:10.3390/ph7080866

The Fungal Defensin Family Enlarged

Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China
*
Author to whom correspondence should be addressed.
Received: 5 June 2014 / Revised: 5 August 2014 / Accepted: 8 August 2014 / Published: 18 August 2014
View Full-Text   |   Download PDF [4030 KB, uploaded 19 August 2014]   |  

Abstract

Fungi are an emerging source of peptide antibiotics. With the availability of a large number of model fungal genome sequences, we can expect that more and more fungal defensin-like peptides (fDLPs) will be discovered by sequence similarity search. Here, we report a total of 69 new fDLPs encoded by 63 genes, in which a group of fDLPs derived from dermatophytes are defined as a new family (fDEF8) according to sequence and phylogenetic analyses. In the oleaginous fungus Mortierella alpine, fDLPs have undergone extensive gene expansion. Our work further enlarges the fungal defensin family and will help characterize new peptide antibiotics with therapeutic potential. View Full-Text
Keywords: peptide antibiotic; gene duplication; exon-intron structure; cysteine-stabilized α-helical and β-sheet motif peptide antibiotic; gene duplication; exon-intron structure; cysteine-stabilized α-helical and β-sheet motif
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wu, J.; Gao, B.; Zhu, S. The Fungal Defensin Family Enlarged. Pharmaceuticals 2014, 7, 866-880.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top