Next Article in Journal
Peptides and Peptidomimetics for Antimicrobial Drug Design
Previous Article in Journal
Tryptophan Breakdown in Patients with HCV Infection is Influenced by IL28B Polymorphism
Previous Article in Special Issue
Recommendations for Probiotic Use in Humans—A 2014 Update
Article Menu

Export Article

Open AccessArticle
Pharmaceuticals 2015, 8(2), 351-365; doi:10.3390/ph8020351

Effects of a Formula Containing Two Types of Prebiotics, Bifidogenic Growth Stimulator and Galacto-oligosaccharide, and Fermented Milk Products on Intestinal Microbiota and Antibody Response to Influenza Vaccine in Elderly Patients: A Randomized Controlled Trial

1
Food Science Research Labs., R&D Division, Meiji Co., Ltd., Odawara, Kanagawa 250-0862, Japan
2
Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan
3
Department of Mechanism of Aging, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan
4
Department of Medicine for Aging in Place and Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Yasuhiro Koga
Received: 26 March 2015 / Revised: 9 June 2015 / Accepted: 11 June 2015 / Published: 18 June 2015
(This article belongs to the Special Issue Probiotics and Prebiotics 2015)
View Full-Text   |   Download PDF [746 KB, uploaded 18 June 2015]

Abstract

We investigated the effect of a formula containing two different prebiotics (bifidogenic growth stimulator and galacto-oligosaccharide) and fermented milk products on intestinal microbiota and antibody responses to an influenza vaccine in enterally fed elderly in-patients. Patients were administered either formula containing prebiotics and fermented milk products (group F: n = 12, 79.9 ± 9.5 years old) or standard formula (group C: n = 12, 80.7 ± 10.1 years old) via percutaneous endoscopic gastrostomy during a 14-week intervention period. Subjects were immunized with an influenza vaccine (A/H1N1, A/H3N2, and B) at week 4 of the intervention. Blood biochemical indices, intestinal bacteria populations and antibody titers were analyzed. Bifidobacterium counts increased significantly in group F compared with group C. The enhanced antibody titers against A/H1N1 were maintained in group F for a longer period compared with group C. The titers against A/H3N2 were unchanged between both groups, and those against B were significantly lower in group F than in group C, although few subjects had seroprotective titers against A/H3N2 and B. These results suggest that administration of the formula containing prebiotics and fermented milk products may maintain antibody titers for longer periods through the improvement of intestinal microbiota. View Full-Text
Keywords: enterally fed patients; Bifidobacterium; hemagglutination inhibition test; seroprotective rate enterally fed patients; Bifidobacterium; hemagglutination inhibition test; seroprotective rate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nagafuchi, S.; Yamaji, T.; Kawashima, A.; Saito, Y.; Takahashi, T.; Yamamoto, T.; Maruyama, M.; Akatsu, H. Effects of a Formula Containing Two Types of Prebiotics, Bifidogenic Growth Stimulator and Galacto-oligosaccharide, and Fermented Milk Products on Intestinal Microbiota and Antibody Response to Influenza Vaccine in Elderly Patients: A Randomized Controlled Trial. Pharmaceuticals 2015, 8, 351-365.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top