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Pharmaceuticals 2010, 3(3), 541-557; doi:10.3390/ph3030541

Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure

 and *
Department of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA
* Author to whom correspondence should be addressed.
Received: 9 January 2010 / Revised: 7 February 2010 / Accepted: 5 March 2010 / Published: 8 March 2010
(This article belongs to the Special Issue Biomarkers)
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Plasma platelet-activating factor acetylhydrolase (PAF-AH), also called lipoprotein-associated phospholipase A2 (Lp-PLA2), is a group VIIA PLA2 enzyme that catalyzes the hydrolysis of PAF and certain oxidized phospholipids. Although the role of PAF-AH as a pro- or anti-atherosclerotic enzyme is highly debated, several studies have shown it to be an independent marker of cardiovascular diseases. In humans the majority of plasma PAF-AH is bound to LDL and a smaller portion to HDL; the majority of the enzyme being associated with small dense LDL and VHDL-1 subclasses. Several studies suggest that the anti- or pro-atherosclerotic tendency of PAF-AH might be dependent on the type of lipoprotein it is associated with. Amino acid residues in PAF-AH necessary for binding to LDL and HDL have been identified. However our understanding of the interaction of PAF-AH with LDL and HDL is still incomplete. In this review we present an overview of what is already known about the interaction of PAF-AH with lipoprotein particles, and we pose questions that are yet to be answered. The recently solved crystal structure of PAF-AH, along with functional work done by others is used as a guide to develop a model of interaction of PAF-AH with lipoprotein particles.
Keywords: PAF-AH; Lp-PLA2; group VIIA PLA2; lipoprotein; i-face PAF-AH; Lp-PLA2; group VIIA PLA2; lipoprotein; i-face
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Srinivasan, P.; Bahnson, B.J. Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure. Pharmaceuticals 2010, 3, 541-557.

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