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Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure
Department of Chemistry & Biochemistry, University of Delaware, Newark, DE, 19716, USA
* Author to whom correspondence should be addressed.
Received: 9 January 2010; in revised form: 7 February 2010 / Accepted: 5 March 2010 / Published: 8 March 2010
(This article belongs to the Special Issue Biomarkers
Abstract: Plasma platelet-activating factor acetylhydrolase (PAF-AH), also called lipoprotein-associated phospholipase A2 (Lp-PLA2), is a group VIIA PLA2 enzyme that catalyzes the hydrolysis of PAF and certain oxidized phospholipids. Although the role of PAF-AH as a pro- or anti-atherosclerotic enzyme is highly debated, several studies have shown it to be an independent marker of cardiovascular diseases. In humans the majority of plasma PAF-AH is bound to LDL and a smaller portion to HDL; the majority of the enzyme being associated with small dense LDL and VHDL-1 subclasses. Several studies suggest that the anti- or pro-atherosclerotic tendency of PAF-AH might be dependent on the type of lipoprotein it is associated with. Amino acid residues in PAF-AH necessary for binding to LDL and HDL have been identified. However our understanding of the interaction of PAF-AH with LDL and HDL is still incomplete. In this review we present an overview of what is already known about the interaction of PAF-AH with lipoprotein particles, and we pose questions that are yet to be answered. The recently solved crystal structure of PAF-AH, along with functional work done by others is used as a guide to develop a model of interaction of PAF-AH with lipoprotein particles.
Keywords: PAF-AH; Lp-PLA2; group VIIA PLA2; lipoprotein; i-face
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Srinivasan, P.; Bahnson, B.J. Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure. Pharmaceuticals 2010, 3, 541-557.
Srinivasan P, Bahnson BJ. Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure. Pharmaceuticals. 2010; 3(3):541-557.
Srinivasan, Prabhavathi; Bahnson, Brian J. 2010. "Molecular Model of Plasma PAF Acetylhydrolase-Lipoprotein Association: Insights from the Structure." Pharmaceuticals 3, no. 3: 541-557.