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Pharmaceuticals 2010, 3(3), 558-571; doi:10.3390/ph3030558
Review

NSAIDs and Acute Pancreatitis: A Systematic Review

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Received: 2 January 2010; in revised form: 11 February 2010 / Accepted: 9 March 2010 / Published: 10 March 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract: The resulting pain is the main symptom of acute pancreatitis and it should be alleviated as soon as possible. NSAIDs are the first line therapy for pain and they are generally administered to acute pancreatitis patients upon admission to the hospital. In addition, these drugs have also been used to prevent post-endoscopic cholangiopancreatography (ERCP) acute pancreatitis. On the other hand, there are several reports indicating that NSAIDs may be the actual cause of acute pancreatitis. We carried out a literature search on PubMed/MEDLINE; all full text papers published in from January 1966 to November 2009 on the use of NSAIDs in acute pancreatitis were collected; the literature search was also supplemented by a review of the bibliographies of the papers evaluated. Thus, in this article, we will systematically review the current literature in order to better illustrate the role of NSAIDs in acute pancreatitis, in particular: i) NSAIDs as a cause of acute pancreatitis; ii) their use to prevent post-retrograde ERCP pancreatitis and iii) their efficacy for pain relief in the acute illness of the pancreas.
Keywords: acute pancreatitis; cytokines; inflammation; arachidonic acid; prostaglandins; leukotrienes; phospholipase A2 acute pancreatitis; cytokines; inflammation; arachidonic acid; prostaglandins; leukotrienes; phospholipase A2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pezzilli, R.; Morselli-Labate, A.M.; Corinaldesi, R. NSAIDs and Acute Pancreatitis: A Systematic Review. Pharmaceuticals 2010, 3, 558-571.

AMA Style

Pezzilli R, Morselli-Labate AM, Corinaldesi R. NSAIDs and Acute Pancreatitis: A Systematic Review. Pharmaceuticals. 2010; 3(3):558-571.

Chicago/Turabian Style

Pezzilli, Raffaele; Morselli-Labate, Antonio Maria; Corinaldesi, Roberto. 2010. "NSAIDs and Acute Pancreatitis: A Systematic Review." Pharmaceuticals 3, no. 3: 558-571.



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