Next Article in Journal
Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates
Next Article in Special Issue
Cell-Penetrating Peptides for Antiviral Drug Development
Previous Article in Journal
Structural Examination of 6-Methylsulphonylphenanthro- [9,10-C]-furan-1(3H)-one—A Rofecoxib Degradation Product
Previous Article in Special Issue
Comparison of Functional Protein Transduction Domains Using the NEMO Binding Domain Peptide
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2010, 3(2), 379-392; doi:10.3390/ph3020379

Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain

Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20157 Milano, Italy
Author to whom correspondence should be addressed.
Received: 18 December 2008 / Revised: 20 January 2010 / Accepted: 28 January 2010 / Published: 3 February 2010
(This article belongs to the Special Issue Cell-penetrating Peptides 2012)
View Full-Text   |   Download PDF [175 KB, uploaded 3 February 2010]   |  


The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS. View Full-Text
Keywords: CPPs; neuroprotection; protein-protein interaction; drug discovery; brain CPPs; neuroprotection; protein-protein interaction; drug discovery; brain

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Antoniou, X.; Borsello, T. Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain. Pharmaceuticals 2010, 3, 379-392.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top