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Pharmaceuticals 2010, 3(2), 369-378; doi:10.3390/ph3020369
Article

Structural Examination of 6-Methylsulphonylphenanthro- [9,10-C]-furan-1(3H)-one—A Rofecoxib Degradation Product

Received: 14 December 2009; in revised form: 12 January 2010 / Accepted: 21 January 2010 / Published: 1 February 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract: In the attempt to discover a new polymorph of rofecoxib (Vioxx®), an unexpected product resulted. The product was characterised by chemical composition, thermal behaviour and structure and found to be 6-methylsulphonylphenanthro-[9,10-C] furan-1(3H)-one, a photo-cyclization degradation product of rofecoxib. This is a significant finding because it indicates that without appropriate control of the recrystallisation procedures, the structural integrity of rofecoxib may be seriously compromised.
Keywords: rofecoxib; structural characterisation; NSAID; crystallography rofecoxib; structural characterisation; NSAID; crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dean, P.M. Structural Examination of 6-Methylsulphonylphenanthro- [9,10-C]-furan-1(3H)-one—A Rofecoxib Degradation Product. Pharmaceuticals 2010, 3, 369-378.

AMA Style

Dean PM. Structural Examination of 6-Methylsulphonylphenanthro- [9,10-C]-furan-1(3H)-one—A Rofecoxib Degradation Product. Pharmaceuticals. 2010; 3(2):369-378.

Chicago/Turabian Style

Dean, Pamela M. 2010. "Structural Examination of 6-Methylsulphonylphenanthro- [9,10-C]-furan-1(3H)-one—A Rofecoxib Degradation Product." Pharmaceuticals 3, no. 2: 369-378.


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