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Pharmaceuticals 2010, 3(2), 393-405; doi:10.3390/ph3020393

Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates

1,* , 2
Received: 24 November 2009 / Revised: 15 January 2010 / Accepted: 21 January 2010 / Published: 3 February 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Non-steroidal anti-inflammatory drugs like ibuprofen or indomethacin are commonly prescribed drugs to induce pharmacologic closure of a patent ductus arteriosus in preterm neonates. Based on a recently published Cochrane meta-analysis, both drugs are equally effective to induce closure. Drug choice can therefore be based on differences in side effects or pharmaco-economic arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiable impact on renal function. However, compared to ibuprofen, the negative impact of indomethacin is more pronounced.
Keywords: non-steroidal anti-inflammatory drugs; renal side effects; quantification non-steroidal anti-inflammatory drugs; renal side effects; quantification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Allegaert, K.; De Hoon, J.; Debeer, A.; Gewillig, M. Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates. Pharmaceuticals 2010, 3, 393-405.

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