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Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
* Author to whom correspondence should be addressed.
Received: 17 June 2009; in revised form: 2 July 2009 / Accepted: 7 July 2009 / Published: 8 July 2009
Abstract: Label-free detections of biomolecules have attracted great attention in a lot of life science fields such as genomics, clinical diagnosis and practical pharmacy. In this article, we reviewed amperometric and potentiometric biosensors based on carbon nanotubes (CNTs). In amperometric detections, CNT-modified electrodes were used as working electrodes to significantly enhance electroactive surface area. In contrast, the potentiometric biosensors were based on aptamer-modified CNT field-effect transistors (CNTFETs). Since aptamers are artificial oligonucleotides and thus are smaller than the Debye length, proteins can be detected with high sensitivity. In this review, we discussed on the technology, characteristics and developments for commercialization in label-free CNT-based biosensors.
Keywords: label-free biosensors; carbon nanotube; prostate-specific antigen; microfludic chips; field-effect transistors; aptamer; IgE
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Cite This Article
MDPI and ACS Style
Maehashi, K.; Matsumoto, K. Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors. Sensors 2009, 9, 5368-5378.
Maehashi K, Matsumoto K. Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors. Sensors. 2009; 9(7):5368-5378.
Maehashi, Kenzo; Matsumoto, Kazuhiko. 2009. "Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors." Sensors 9, no. 7: 5368-5378.