A correction was published on 8 January 2009, see Sensors 2009, 9(1), 377.

Sensors 2008, 8(12), 8321-8360; doi:10.3390/s8128321
Review

Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds

1 Vinča Institute of Nuclear Sciences, Department of Physical Chemistry, 11001 Belgrade, Republic of Serbia 2 Institute of Medicinal Chemistry, University School of Medicine, University of Belgrade, Višegradska 12, Belgrade, Republic of Serbia
* Author to whom correspondence should be addressed.
Received: 3 November 2008; in revised form: 9 November 2008 / Accepted: 11 December 2008 / Published: 15 December 2008
(This article belongs to the Special Issue Toxin Sensors)
PDF Full-text Download PDF Full-Text [428 KB, uploaded 15 December 2008 15:49 CET]
Abstract: This paper gives an overview of the literature data concerning specific and non specific inhibitors of Na+,K+-ATPase receptor. The immobilization approaches developed to improve the rather low time and temperature stability of Na+,K+-ATPase, as well to preserve the enzyme properties were overviewed. The functional immobilization of Na+,K+-ATPase receptor as the target, with preservation of the full functional protein activity and access of various substances to an optimum number of binding sites under controlled conditions in the combination with high sensitive technology for the detection of enzyme activity is the basis for application of this enzyme in medical, pharmaceutical and environmental research.
Keywords: Na+; K+-ATPase; toxic agents; inhibition; detection; sensor

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Vasić, V.; Momić, T.; Petković, M.; Krstić, D. Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds. Sensors 2008, 8, 8321-8360.

AMA Style

Vasić V, Momić T, Petković M, Krstić D. Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds. Sensors. 2008; 8(12):8321-8360.

Chicago/Turabian Style

Vasić, Vesna; Momić, Tatjana; Petković, Marijana; Krstić, Danijela. 2008. "Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds." Sensors 8, no. 12: 8321-8360.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert