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• Taitt, C
• Shriver-Lake, LC.
• Ngundi, MM.
• Ligler, FS.
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• Shriver-Lake, LC.
• Ngundi, MM.
• Ligler, FS.
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• Shriver-Lake, LC.
• Ngundi, MM.
• Ligler, FS.

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Sensors 2008, 8(12), 8361-8377; doi:10.3390/s8128361

Review

Array Biosensor for Toxin Detection: Continued Advances

Chris Rowe Taitt ^1,* , Lisa C. Shriver-Lake ¹ , Miriam M. Ngundi ²  and Frances S. Ligler ¹

¹ Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Code 6900, Washington, DC 20375-5348, USA ² Food and Drug Administration, N29 RM418 HFM-434, 8800 Rockville Pike, Bethesda, MD 20892, USA

* Author to whom correspondence should be addressed.

Received: 31 October 2008; in revised form: 26 November 2008 / Accepted: 9 December 2008 / Published: 15 December 2008

(This article belongs to the Special Issue Toxin Sensors)

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Abstract: The following review focuses on progress made in the last five years with the NRL Array Biosensor, a portable instrument for rapid and simultaneous detection of multiple targets. Since 2003, the Array Biosensor has been automated and miniaturized for operation at the point-of-use. The Array Biosensor has also been used to demonstrate (1) quantitative immunoassays against an expanded number of toxins and toxin indicators in food and clinical fluids, and (2) the efficacy of semi-selective molecules as alternative recognition moieties. Blind trials, with unknown samples in a variety of matrices, have demonstrated the versatility, sensitivity, and reliability of the automated system.

Keywords: toxin; detection; biosensor; multi-analyte; multiplex; food; clinical diagnostics

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