Next Article in Journal
Na+,K+-ATPase as the Target Enzyme for Organic and Inorganic Compounds
Previous Article in Journal
Comparison of a Resonant Mirror Biosensor (IAsys) and a Quartz Crystal Microbalance (QCM) for the Study on Interaction between Paeoniae Radix 801 and Endothelin-1
Previous Article in Special Issue
Recent Progress in Nucleic Acid Aptamer-Based Biosensors and Bioassays
Article Menu

Export Article

Open AccessReview
Sensors 2008, 8(12), 8291-8320; doi:10.3390/s8128291

Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

Key Laboratory of Biomimetic Sensing & Advanced Robot Technology, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui 230031, P.R. China
Author to whom correspondence should be addressed.
Received: 7 November 2008 / Revised: 21 November 2008 / Accepted: 9 December 2008 / Published: 15 December 2008
(This article belongs to the Special Issue Molecular Recognition and Sensors, Including Molecular Imprinting)
View Full-Text   |   Download PDF [1172 KB, uploaded 21 June 2014]   |  


Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given. View Full-Text
Keywords: Molecularly imprinted polymers; Nanostructures; Chemical detection; Sensors Molecularly imprinted polymers; Nanostructures; Chemical detection; Sensors

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Guan, G.; Liu, B.; Wang, Z.; Zhang, Z. Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors. Sensors 2008, 8, 8291-8320.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top