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Sensors 2008, 8(12), 8291-8320; doi:10.3390/s8128291
Review

Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

, ,  and *
Received: 7 November 2008; in revised form: 21 November 2008 / Accepted: 9 December 2008 / Published: 15 December 2008
(This article belongs to the Special Issue Molecular Recognition and Sensors, Including Molecular Imprinting)
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Abstract: Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given.
Keywords: Molecularly imprinted polymers; Nanostructures; Chemical detection; Sensors Molecularly imprinted polymers; Nanostructures; Chemical detection; Sensors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Guan, G.; Liu, B.; Wang, Z.; Zhang, Z. Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors. Sensors 2008, 8, 8291-8320.

AMA Style

Guan G, Liu B, Wang Z, Zhang Z. Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors. Sensors. 2008; 8(12):8291-8320.

Chicago/Turabian Style

Guan, Guijian; Liu, Bianhua; Wang, Zhenyang; Zhang, Zhongping. 2008. "Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors." Sensors 8, no. 12: 8291-8320.



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