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Sensors 2016, 16(2), 196; doi:10.3390/s16020196

A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications

1
Department of Industrial and Information Engineering, Second University of Naples, Via Roma 29, Aversa 81031, Italy
2
Institute of Applied Physics “Nello Carrara”, CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 2 December 2015 / Revised: 21 January 2016 / Accepted: 1 February 2016 / Published: 4 February 2016
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [2343 KB, uploaded 4 February 2016]   |  

Abstract

An optical sensor platform based on surface plasmon resonance (SPR) in a plastic optical fiber (POF) integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG)/anti-IgG assay. View Full-Text
Keywords: flow cell; surface plasmon resonance; plastic optical fiber; sensors system; biosensors flow cell; surface plasmon resonance; plastic optical fiber; sensors system; biosensors
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MDPI and ACS Style

Cennamo, N.; Chiavaioli, F.; Trono, C.; Tombelli, S.; Giannetti, A.; Baldini, F.; Zeni, L. A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications. Sensors 2016, 16, 196.

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