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Applications of Aptasensors in Clinical Diagnostics
National Center for Clinical Laboratories, Beijing Hospital, Beijing 100730, China
Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
* Author to whom correspondence should be addressed.
Received: 19 December 2011; in revised form: 11 January 2012 / Accepted: 29 January 2012 / Published: 30 January 2012
Abstract: Aptamers are artificial oligonucleotides (DNA or RNA) selected in vitro that bind a broad range of targets with high affinity and specificity; a sensitive yet simple method to utilize aptamers as recognition elements for the development of biosensors (aptasensors) is to transduce the signal electrochemically. So far, aptasensors have been applied to clinical diagnostics and several technologies are in development. Aptasensors will extend the limits of current clinical diagnostics. Although the potential diagnostic applications are unlimited, the most current applications are foreseen in the areas of biomarker detection, cancer clinical testing, detection of infectious microorganisms and viruses. This review attempts to list examples of the research progresses of aptamers in biosensor platforms that have been published in recent years; in particular, we display cases of aptasensors that are already incorporated in clinical diagnostics or have potential applications in clinical diagnostics.
Keywords: biosensor; aptamer; aptasensors; clinical diagnostics
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MDPI and ACS Style
Hong, P.; Li, W.; Li, J. Applications of Aptasensors in Clinical Diagnostics. Sensors 2012, 12, 1181-1193.
Hong P, Li W, Li J. Applications of Aptasensors in Clinical Diagnostics. Sensors. 2012; 12(2):1181-1193.
Hong, Ping; Li, Wenli; Li, Jinming. 2012. "Applications of Aptasensors in Clinical Diagnostics." Sensors 12, no. 2: 1181-1193.