Next Article in Journal
Objective Display and Discrimination of Floral Odors from Amorphophallus titanum, Bloomed on Different Dates and at Different Locations, Using an Electronic Nose
Previous Article in Journal
Experimental Assessment of Different Receiver Structures for Underwater Acoustic Communications over Multipath Channels
Previous Article in Special Issue
Applications of Aptasensors in Clinical Diagnostics
Article Menu

Export Article

Open AccessReview
Sensors 2012, 12(2), 2136-2151; doi:10.3390/s120202136

Waveguide-Mode Sensors as Aptasensors

Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan
*
Authors to whom correspondence should be addressed.
Received: 11 January 2012 / Revised: 7 February 2012 / Accepted: 8 February 2012 / Published: 15 February 2012
(This article belongs to the Special Issue Aptamer-Based Sensors)
View Full-Text   |   Download PDF [960 KB, uploaded 21 June 2014]   |  

Abstract

Aptamers are artificial nucleic acid ligands that can be generated by in vitro selection through partition and amplification. Aptamers can be generated against a wide range of biomolecules through the formation of versatile stem-loop structures. Because aptamers are potential substitutes for antibodies and drugs, the development of an aptamer-based sensor (aptasensor) is mandatory for diagnosis. We previously reported that waveguide-mode sensors are useful in the analysis of a wide range of biomolecular interactions, including aptamers. The advantages of the waveguide-mode sensor that we developed include physical and chemical stability and that higher sensitivity can be achieved with ease by perforating the waveguide layer or using colored materials such as dyes or metal nanoparticles as labels. Herein, we provide an overview of the strategies and applications for aptamer-based analyses using waveguide-mode sensors.
Keywords: waveguide; aptamer; aptasensor; optics; SELEX waveguide; aptamer; aptasensor; optics; SELEX
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gopinath, S.C.B.; Awazu, K.; Fujimaki, M. Waveguide-Mode Sensors as Aptasensors. Sensors 2012, 12, 2136-2151.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top