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Applications of Aptasensors in Clinical Diagnostics
Sensors 2012, 12(2), 2136-2151; doi:10.3390/s120202136
Review

Waveguide-Mode Sensors as Aptasensors

* ,
 and *
Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan
* Authors to whom correspondence should be addressed.
Received: 11 January 2012 / Revised: 7 February 2012 / Accepted: 8 February 2012 / Published: 15 February 2012
(This article belongs to the Special Issue Aptamer-Based Sensors)
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Abstract

Aptamers are artificial nucleic acid ligands that can be generated by in vitro selection through partition and amplification. Aptamers can be generated against a wide range of biomolecules through the formation of versatile stem-loop structures. Because aptamers are potential substitutes for antibodies and drugs, the development of an aptamer-based sensor (aptasensor) is mandatory for diagnosis. We previously reported that waveguide-mode sensors are useful in the analysis of a wide range of biomolecular interactions, including aptamers. The advantages of the waveguide-mode sensor that we developed include physical and chemical stability and that higher sensitivity can be achieved with ease by perforating the waveguide layer or using colored materials such as dyes or metal nanoparticles as labels. Herein, we provide an overview of the strategies and applications for aptamer-based analyses using waveguide-mode sensors.
Keywords: waveguide; aptamer; aptasensor; optics; SELEX waveguide; aptamer; aptasensor; optics; SELEX
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gopinath, S.C.B.; Awazu, K.; Fujimaki, M. Waveguide-Mode Sensors as Aptasensors. Sensors 2012, 12, 2136-2151.

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