Special Issue "Aptamer-Based Sensors"
A special issue of Sensors (ISSN 1424-8220).
Deadline for manuscript submissions: closed (30 October 2011)
Prof. Dr. Dipankar Sen (Website)
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
Interests: DNA; RNA; ribozymes; deoxyribozymes; in vitro selection; catalysis; charge transfer; biosensors; photochemistry
Antibodies have been the traditional sensing platform underlying sensor design for the detection of biomedically and environmentally important “analytes”. However, in recent years, “aptamers”—DNA and RNA molecules with antibody-like properties of high-affinity and -specificity binding to analytes of interest—have started to assert themselves in the latest generations of sensors. In a number of ways, aptamers make excellent substitutes for antibodies: they are chemically stable, easily and inexpensively synthesized, and do not elicit a significant immune response if used in vivo. However, the isolation of a high-quality aptamer against a designated analyte does not in itself guarantee its usefulness as a biosensor; there is also the necessity for an effective transduction mechanism, such that analyte binding generates a quantifiable output (often optical or electronic) signal. This special issue of Sensors focuses on the variety of elegant approaches that have recently been taken to generate aptamer-based sensors—a new paradigm in analyte detection.
Prof. Dr. Dipankar Sen