Special Issue "Aptamer-Based Sensors"
A special issue of Sensors (ISSN 1424-8220).
Deadline for manuscript submissions: closed (30 October 2011)
Prof. Dr. Dipankar Sen
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
Interests: DNA; RNA; ribozymes; deoxyribozymes; in vitro selection; catalysis; charge transfer; biosensors; photochemistry
Antibodies have been the traditional sensing platform underlying sensor design for the detection of biomedically and environmentally important “analytes”. However, in recent years, “aptamers”—DNA and RNA molecules with antibody-like properties of high-affinity and -specificity binding to analytes of interest—have started to assert themselves in the latest generations of sensors. In a number of ways, aptamers make excellent substitutes for antibodies: they are chemically stable, easily and inexpensively synthesized, and do not elicit a significant immune response if used in vivo. However, the isolation of a high-quality aptamer against a designated analyte does not in itself guarantee its usefulness as a biosensor; there is also the necessity for an effective transduction mechanism, such that analyte binding generates a quantifiable output (often optical or electronic) signal. This special issue of Sensors focuses on the variety of elegant approaches that have recently been taken to generate aptamer-based sensors—a new paradigm in analyte detection.
Prof. Dr. Dipankar Sen
Sensors 2011, 11(9), 8953-8965; doi:10.3390/s110908953
Received: 21 July 2011; in revised form: 27 August 2011 / Accepted: 15 September 2011 / Published: 19 September 2011| Download PDF Full-text (791 KB) | Download XML Full-text
Article: Human Thrombin Detection Through a Sandwich Aptamer Microarray: Interaction Analysis in Solution and in Solid Phase
Sensors 2011, 11(10), 9426-9441; doi:10.3390/s111009426
Received: 29 July 2011; in revised form: 27 September 2011 / Accepted: 28 September 2011 / Published: 3 October 2011| Download PDF Full-text (469 KB) | Download XML Full-text
Article: A Conjugated Aptamer-Gold Nanoparticle Fluorescent Probe for Highly Sensitive Detection of rHuEPO-α
Sensors 2011, 11(11), 10490-10501; doi:10.3390/s111110490
Received: 24 August 2011; in revised form: 11 October 2011 / Accepted: 1 November 2011 / Published: 3 November 2011| Download PDF Full-text (709 KB) | Download XML Full-text
Sensors 2012, 12(2), 1181-1193; doi:10.3390/s120201181
Received: 19 December 2011; in revised form: 11 January 2012 / Accepted: 29 January 2012 / Published: 30 January 2012| Download PDF Full-text (366 KB) | Download XML Full-text
Sensors 2012, 12(2), 2136-2151; doi:10.3390/s120202136
Received: 11 January 2012; in revised form: 7 February 2012 / Accepted: 8 February 2012 / Published: 15 February 2012| Download PDF Full-text (960 KB) | Download XML Full-text
Last update: 4 March 2014