Next Article in Journal
Estimating Three-Dimensional Orientation of Human Body Parts by Inertial/Magnetic Sensing
Next Article in Special Issue
Overview of the Characteristics of Micro- and Nano-Structured Surface Plasmon Resonance Sensors
Previous Article in Journal
A Parkinson’s Disease Measurement System Using Laser Lines and a CMOS Image Sensor
Previous Article in Special Issue
Active Integrated Filters for RF-Photonic Channelizers
Article Menu

Export Article

Open AccessArticle
Sensors 2011, 11(2), 1476-1488; doi:10.3390/s110201476

Resonant Photonic Biosensors with Polarization-Based Multiparametric Discrimination in Each Channel

1
Department of Electrical Engineering, University of Texas at Arlington, Box 19016, Arlington, TX 76019, USA
2
Resonant Sensors Incorporated, 416 Yates Street, 518 NH, Arlington, TX 76010, USA
*
Author to whom correspondence should be addressed.
Received: 10 December 2010 / Revised: 4 January 2011 / Accepted: 18 January 2011 / Published: 26 January 2011
(This article belongs to the Special Issue Optical Resonant Microsensors)
View Full-Text   |   Download PDF [456 KB, 21 June 2014; original version 21 June 2014]   |  

Abstract

In this paper, we describe guided-mode resonance biochemical sensor technology. We briefly discuss sensor fabrication and show measured binding dynamics for example biomaterials in use in our laboratories. We then turn our attention to a particularly powerful attribute of this technology not possessed by competing methods. This attribute is the facile generation of multiple resonance peaks at an identical physical location on the sensor surface. These peaks respond uniquely to the biomolecular event, thereby enriching the data set available for event quantification. The peaks result from individual, polarization-dependent resonant leaky modes that are the foundation of this technology. Thus, by modeling the binding event and fitting to a rigorous electromagnetic formalism, we can determine individual attributes of the biolayer and its surroundings and avoid a separate reference site for background monitoring. Examples provide dual-polarization quantification of biotin binding to a silane-coated sensor as well as binding of the cancer biomarker protein calreticulin to its monoclonal IgG capture antibody. Finally, we present dual-polarization resonance response for poly (allylamine hydrochloride) binding to the sensor with corresponding results of backfitting to a simple model; this differentiates the contributions from biolayer adhesion and background changes.
Keywords: guided-mode resonance sensors; leaky-mode resonance; periodic elements; biosensors; label-free sensors guided-mode resonance sensors; leaky-mode resonance; periodic elements; biosensors; label-free sensors
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Magnusson, R.; Wawro, D.; Zimmerman, S.; Ding, Y. Resonant Photonic Biosensors with Polarization-Based Multiparametric Discrimination in Each Channel. Sensors 2011, 11, 1476-1488.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top