Sensors 2010, 10(10), 9127-9138; doi:10.3390/s101009127

Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma

1 Department of Pulmonology, Semmelweis University, Diósárok u. 1/c, 1125 Budapest, Hungary 2 Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 3 Department of Pulmonology, Medical Centre Leeuwarden, PO Box 888, 8901 BR Leeuwarden, The Netherlands
* Author to whom correspondence should be addressed.
Received: 10 August 2010; in revised form: 15 September 2010 / Accepted: 25 September 2010 / Published: 12 October 2010
(This article belongs to the Special Issue Direct and Indirect Sensing of Odor and VOCs and Their Control)
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Abstract: Molecular profiling of exhaled volatile organic compounds (VOC) by electronic nose technology provides breathprints that discriminate between patients with different inflammatory airway diseases, such as asthma and COPD. However, it is unknown whether this is determined by differences in airway caliber. We hypothesized that breathprints obtained by electronic nose are independent of acute changes in airway caliber in asthma. Ten patients with stable asthma underwent methacholine provocation (Visit 1) and sham challenge with isotonic saline (Visit 2). At Visit 1, exhaled air was repetitively collected pre-challenge, after reaching the provocative concentration (PC20) causing 20% fall in forced expiratory volume in 1 second (FEV1) and after subsequent salbutamol inhalation. At Visit 2, breath was collected pre-challenge, post-saline and post-salbutamol. At each occasion, an expiratory vital capacity was collected after 5 min of tidal breathing through an inspiratory VOC-filter in a Tedlar bag and sampled by electronic nose (Cyranose 320). Breathprints were analyzed with principal component analysis and individual factors were compared with mixed model analysis followed by pairwise comparisons. Inhalation of methacholine led to a 30.8 ± 3.3% fall in FEV1 and was followed by a significant change in breathprint (p = 0.04). Saline inhalation did not induce a significant change in FEV1, but altered the breathprint (p = 0.01). However, the breathprint obtained after the methacholine provocation was not significantly different from that after saline challenge (p = 0.27). The molecular profile of exhaled air in patients with asthma is altered by nebulized aerosols, but is not affected by acute changes in airway caliber. Our data demonstrate that breathprints by electronic nose are not confounded by the level of airway obstruction.
Keywords: volatile organic compounds; exhaled breathprint; electronic nose; pattern recognition; airway caliber; bronchial asthma; bronchial provocation

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MDPI and ACS Style

Lazar, Z.; Fens, N.; Maten, J.; Schee, M.P.; Wagener, A.H.; Nijs, S.B.; Dijkers, E.; Sterk, P.J. Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma. Sensors 2010, 10, 9127-9138.

AMA Style

Lazar Z, Fens N, Maten J, Schee MP, Wagener AH, Nijs SB, Dijkers E, Sterk PJ. Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma. Sensors. 2010; 10(10):9127-9138.

Chicago/Turabian Style

Lazar, Zsofia; Fens, Niki; Maten, Jan van der; Schee, Marc P. van der; Wagener, Ariane H.; Nijs, Selma B. de; Dijkers, Erica; Sterk, Peter J. 2010. "Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma." Sensors 10, no. 10: 9127-9138.

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