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Int. J. Mol. Sci. 2016, 17(10), 1553; doi:10.3390/ijms17101553

Circulating MicroRNAs as Potential Biomarkers of Exercise Response

1
Hamar Institute for Human Performance, Faculty of Physical Education and Sports, Comenius University Bratislava, Nábr. Arm. Gen. L. Svobodu 9, Bratislava 814 69, Slovakia
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojárov 10, Bratislava 832 32, Slovakia
3
Department of Track & Field, Faculty of Physical Education and Sports, Comenius University Bratislava, Nábr. Arm. Gen. L. Svobodu 9, Bratislava 814 69, Slovakia
4
Department of Sport Kinanthropology, Faculty of Physical Education and Sports, Comenius University Bratislava, Nábr. Arm. Gen. L. Svobodu 9, Bratislava 814 69, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 6 July 2016 / Revised: 6 September 2016 / Accepted: 6 September 2016 / Published: 5 October 2016
(This article belongs to the Special Issue microRNA Regulation 2017)
View Full-Text   |   Download PDF [664 KB, uploaded 5 October 2016]   |  

Abstract

Systematic physical activity increases physical fitness and exercise capacity that lead to the improvement of health status and athletic performance. Considerable effort is devoted to identifying new biomarkers capable of evaluating exercise performance capacity and progress in training, early detection of overtraining, and monitoring health-related adaptation changes. Recent advances in OMICS technologies have opened new opportunities in the detection of genetic, epigenetic and transcriptomic biomarkers. Very promising are mainly small non-coding microRNAs (miRNAs). miRNAs post-transcriptionally regulate gene expression by binding to mRNA and causing its degradation or inhibiting translation. A growing body of evidence suggests that miRNAs affect many processes and play a crucial role not only in cell differentiation, proliferation and apoptosis, but also affect extracellular matrix composition and maintaining processes of homeostasis. A number of studies have shown changes in distribution profiles of circulating miRNAs (c-miRNAs) associated with various diseases and disorders as well as in samples taken under physiological conditions such as pregnancy or physical exercise. This overview aims to summarize the current knowledge related to the response of blood c-miRNAs profiles to different modes of exercise and to highlight their potential application as a novel class of biomarkers of physical performance capacity and training adaptation. View Full-Text
Keywords: circulating microRNA; biomarker; physical exercise; skeletal muscle circulating microRNA; biomarker; physical exercise; skeletal muscle
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MDPI and ACS Style

Polakovičová, M.; Musil, P.; Laczo, E.; Hamar, D.; Kyselovič, J. Circulating MicroRNAs as Potential Biomarkers of Exercise Response. Int. J. Mol. Sci. 2016, 17, 1553.

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