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Int. J. Mol. Sci. 2015, 16(7), 15531-15545; doi:10.3390/ijms160715531

Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis

1
Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan
2
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
3
Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan
4
Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
5
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
6
VGH-YM Genomic Research Center, National Yang-Ming University, Taipei 112, Taiwan
7
Department of Pharmacy, Taipei Veterans General Hospital, Taipei 112, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Wenbin Deng
Received: 8 June 2015 / Revised: 6 July 2015 / Accepted: 6 July 2015 / Published: 9 July 2015
View Full-Text   |   Download PDF [795 KB, uploaded 9 July 2015]   |  

Abstract

Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (Parps) family for post-translational modification in cellular process. Being a major member of Parps, Parp1 is a crucial nuclear factor with biological significance in modulating DNA repair, DNA replication, transcription, DNA methylation and chromatin remodeling through PARylation of downstream proteins. In addition, high expression level and activity of Parp1 are correlated with pluripotent status, reprogramming, and cancer. Furthermore, epigenetic modulation of Parp1 is explored for regulating wide variety of gene expression. Genetic and pharmaceutical disruption of Parp1 further confirmed the importance of Parp1 in cell growth, DNA repair, and reprogramming efficiency. Taken together, the proximity toward the understanding of the modulation of Parp1 including interaction and modification in different fields will provide new insight for future studies. In this review, the biological significance of Parp1 in transcription and the epigenetic modulation of Parp1 in pluripotent status, reprogramming process and cancer will be summarized. View Full-Text
Keywords: Parp1; PARylation; pluripotency; reprogramming; tumorogenesis Parp1; PARylation; pluripotency; reprogramming; tumorogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jiang, B.-H.; Tseng, W.-L.; Li, H.-Y.; Wang, M.-L.; Chang, Y.-L.; Sung, Y.-J.; Chiou, S.-H. Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis. Int. J. Mol. Sci. 2015, 16, 15531-15545.

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