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Int. J. Mol. Sci. 2015, 16(5), 9283-9302; doi:10.3390/ijms16059283

Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

1,2,3,†
,
2,†
,
3,†
,
1
,
1
and
1,3,*
1
Medical College, Hubei University of Arts and Science, Xiangyang 441053, China
2
Department of Biological Treatment, Handan Central Hospital, Handan 056001, China
3
Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA 95817, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 10 April 2015 / Revised: 20 April 2015 / Accepted: 20 April 2015 / Published: 24 April 2015
View Full-Text   |   Download PDF [1077 KB, uploaded 24 April 2015]   |  

Abstract

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS. View Full-Text
Keywords: mesenchymal stem cells; induced pluripotent stem cells; neural stem cell; multiple sclerosis mesenchymal stem cells; induced pluripotent stem cells; neural stem cell; multiple sclerosis
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MDPI and ACS Style

Xiao, J.; Yang, R.; Biswas, S.; Qin, X.; Zhang, M.; Deng, W. Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis. Int. J. Mol. Sci. 2015, 16, 9283-9302.

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