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Int. J. Mol. Sci. 2015, 16(7), 15497-15530; doi:10.3390/ijms160715497

A Review: Proteomics in Nasopharyngeal Carcinoma

1,2,†
,
1,2,†
and
1,2,*
1
Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University and Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China
2
Key Laboratories of High-Incidence-Tumour Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning 530021, China
These authors contributed to the work equally.
*
Author to whom correspondence should be addressed.
Academic Editor: David Sheehan
Received: 17 May 2015 / Revised: 8 June 2015 / Accepted: 1 July 2015 / Published: 8 July 2015
(This article belongs to the Collection Advances in Proteomic Research)
View Full-Text   |   Download PDF [775 KB, uploaded 8 July 2015]   |  

Abstract

Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance and that can diagnosis early stages of NPC would be highly useful to improve this situation. Proteomics is widely used in NPC for searching biomarkers and comparing differentially expressed proteins. In this review, an overview of proteomics with different samples related to NPC and common proteomics methods was made. In conclusion, identical proteins are sorted as follows: Keratin is ranked the highest followed by such proteins as annexin, heat shock protein, 14-3-3σ, nm-23 protein, cathepsin, heterogeneous nuclear ribonucleoproteins, enolase, triosephosphate isomerase, stathmin, prohibitin, and vimentin. This ranking indicates that these proteins may be NPC-related proteins and have potential value for further studies. View Full-Text
Keywords: nasopharyngeal carcinoma; NPC (nasopharyngeal carcinoma); proteomics; two-dimensional electrophoresis; mass spectrometry; biomarker; differentially expressed proteins nasopharyngeal carcinoma; NPC (nasopharyngeal carcinoma); proteomics; two-dimensional electrophoresis; mass spectrometry; biomarker; differentially expressed proteins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, Z.-T.; Liang, Z.-G.; Zhu, X.-D. A Review: Proteomics in Nasopharyngeal Carcinoma. Int. J. Mol. Sci. 2015, 16, 15497-15530.

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