Next Article in Journal
Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
Next Article in Special Issue
Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
Previous Article in Journal
Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy
Previous Article in Special Issue
New Therapies for Dedifferentiated Papillary Thyroid Cancer
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(4), 7655-7671; doi:10.3390/ijms16047655

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 1 January 2015 / Revised: 30 March 2015 / Accepted: 30 March 2015 / Published: 7 April 2015
(This article belongs to the Special Issue Advances in Molecular Oncology 2014)
View Full-Text   |   Download PDF [3645 KB, uploaded 7 April 2015]   |  

Abstract

There is increasing evidence that prenatal exposure to environmental factors may modify breast cancer risk later in life. This study aimed to investigate the effects of in utero exposure to low-dose alcohol on mammary development and tumor risk. Pregnant MMTV-erbB-2 mice were exposed to alcohol (6 g/kg/day) between day 13 and day 19 of gestation, and the female offspring were examined for tumor risk. Whole mount analysis indicated that in utero exposure to low-dose alcohol induced significant increases in ductal extension at 10 weeks of age. Molecular analysis showed that in utero alcohol exposure induced upregulation of ERα signaling and activation of Akt and Erk1/2 in pubertal mammary glands. However, enhanced signaling in the EGFR/erbB-2 pathway appeared to be more prominent in 10-week-old glands than did signaling in the other pathways. Interestingly, tumor development in mice with in utero exposure to low-dose alcohol was slightly delayed compared to control mice, but tumor multiplicity was increased. The results indicate that in utero exposure to low-dose alcohol induces the reprogramming of mammary development by mechanisms that include altered signaling in the estrogen receptor (ER) and erbB-2 pathways. The intriguing tumor development pattern might be related to alcohol dose and exposure conditions, and warrants further investigation. View Full-Text
Keywords: alcohol; in utero exposure; breast cancer risk; estrogen receptor; erbB-2; reprogramming alcohol; in utero exposure; breast cancer risk; estrogen receptor; erbB-2; reprogramming
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ma, Z.; Blackwelder, A.J.; Lee, H.; Zhao, M.; Yang, X. In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice. Int. J. Mol. Sci. 2015, 16, 7655-7671.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top