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Int. J. Mol. Sci. 2015, 16(4), 7672-7681; doi:10.3390/ijms16047672

Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering

1
Department of Biochemistry, College of Medicine, Inha University, Incheon 400-712, Korea
2
Department of Biomedical Chemistry, Konkuk University, Chung-Ju 380-701, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Qiang Chen
Received: 12 February 2015 / Revised: 27 March 2015 / Accepted: 31 March 2015 / Published: 7 April 2015
(This article belongs to the Special Issue Protein Engineering)
View Full-Text   |   Download PDF [1120 KB, uploaded 7 April 2015]   |  

Abstract

Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (p < 0.05). View Full-Text
Keywords: bone morphogenetic protein; cell adhesion; cell differentiation; fibronectin; MC3T3 cells bone morphogenetic protein; cell adhesion; cell differentiation; fibronectin; MC3T3 cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lee, S.; Lee, D.-S.; Choi, I.; Pham, L.B.H.; Jang, J.-H. Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering. Int. J. Mol. Sci. 2015, 16, 7672-7681.

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