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Int. J. Mol. Sci. 2015, 16(4), 7944-7959; doi:10.3390/ijms16047944

Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment

1
Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, 2340000 Valparaíso, Chile
2
Department of Biomedical Sciences, University of Catania, V. le A. Doria 6, 95125 Catania, Italy
3
Departamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, 2340000 Valparaíso, Chile
4
Escuela de Obstetricia y Puericultura, Facultad de medicina, Universidad de Valparaíso, Blanco N° 1911, 2340000 Valparaíso, Chile
5
Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda N° 2664, 2340000 Valparaíso, Chile
6
Department of Drug Sciences, Biochemistry Section, University of Catania, V. le A. Doria 6, 95125 Catania, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 12 March 2015 / Revised: 30 March 2015 / Accepted: 31 March 2015 / Published: 9 April 2015
(This article belongs to the Special Issue Advances in Molecular Oncology 2014)
View Full-Text   |   Download PDF [1962 KB, uploaded 9 April 2015]   |  

Abstract

With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on melanoma cancer, the present study was undertaken to investigate the biological activity of the resinous exudate of aerial parts from Psoralea glandulosa, and its active components (bakuchiol (1), 3-hydroxy-bakuchiol (2) and 12-hydroxy-iso-bakuchiol (3)) against melanoma cells (A2058). In addition, the effect in cancer cells of bakuchiol acetate (4), a semi-synthetic derivative of bakuchiol, was examined. The results obtained show that the resinous exudate inhibited the growth of cancer cells with IC50 value of 10.5 μg/mL after 48 h of treatment, while, for pure compounds, the most active was the semi-synthetic compound 4. Our data also demonstrate that resin is able to induce apoptotic cell death, which could be related to an overall action of the meroterpenes present. In addition, our data seem to indicate that the apoptosis correlated to the tested products appears, at least in part, to be associated with an increase of reactive oxygen species (ROS) production. In summary, our study provides the first evidence that P. glandulosa may be considered a source of useful molecules in the development of analogues with more potent efficacy against melanoma cells. View Full-Text
Keywords: Psoralea glandulosa; resinous exudates; bakuchiol acetate; A2058 melanoma cells Psoralea glandulosa; resinous exudates; bakuchiol acetate; A2058 melanoma cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Madrid, A.; Cardile, V.; González, C.; Montenegro, I.; Villena, J.; Caggia, S.; Graziano, A.; Russo, A. Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment. Int. J. Mol. Sci. 2015, 16, 7944-7959.

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