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Int. J. Mol. Sci. 2015, 16(4), 7644-7654; doi:10.3390/ijms16047644

Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy

1
Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano, Nigeria
2
Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden
3
Department of Chemical Pathology, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria
4
Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Yi-Han Chen
Received: 17 January 2015 / Revised: 7 March 2015 / Accepted: 31 March 2015 / Published: 7 April 2015
(This article belongs to the Special Issue Pathogenesis of Cardiac Arrhythmias and Heart Failure)
View Full-Text   |   Download PDF [680 KB, uploaded 7 April 2015]

Abstract

The study aimed to determine if selenium deficiency, serum ceruloplasmin and traditional birth practices are risk factors for peripartum cardiomyopathy (PPCM), in Kano, Nigeria. This is a case-control study carried out in three hospitals, and PPCM patients were followed up for six months. Critically low serum selenium concentration was defined as <70 µg/L. A total of 39 PPCM patients and 50 controls were consecutively recruited after satisfying the inclusion criteria. Mean serum selenium in patients (61.7 ± 14.9 µg/L) was significantly lower than in controls (118.4 ± 45.6 µg/L) (p < 0.001). The prevalence of serum selenium <70 µg/L was significantly higher among patients (76.9%) than controls (22.0%) (p < 0.001). The mean ceruloplasmin and prevalence of socio-economic indices, multiparity, pregnancy-induced hypertension, obesity and twin pregnancy were not different between the groups (p > 0.05). Logistic regression showed that rural residency significantly increased the odds for serum selenium <70 µg/L by 2.773-fold (p = 0.037). Baseline serum levels of selenium and ceruloplasmin were not associated with six-month mortality. This study has shown that selenium deficiency is a risk factor for PPCM in Kano, Nigeria, and is related to rural residency. However, serum ceruloplasmin, customary birth practices and some other characteristics were not associated with PPCM in the study area. View Full-Text
Keywords: peripartum cardiomyopathy; risk factors; selenium deficiency; ceruloplasmin; heart failure peripartum cardiomyopathy; risk factors; selenium deficiency; ceruloplasmin; heart failure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Karaye, K.M.; Yahaya, I.A.; Lindmark, K.; Henein, M.Y. Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy. Int. J. Mol. Sci. 2015, 16, 7644-7654.

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