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Int. J. Mol. Sci. 2014, 15(2), 3118-3144; doi:10.3390/ijms15023118
Review

Genetics of Oxidative Stress in Obesity

,  and *
Received: 15 January 2014; in revised form: 12 February 2014 / Accepted: 12 February 2014 / Published: 20 February 2014
(This article belongs to the Special Issue Nutritional Control of Metabolism)
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Abstract: Obesity is a multifactorial disease characterized by the excessive accumulation of fat in adipose tissue and peripheral organs. Its derived metabolic complications are mediated by the associated oxidative stress, inflammation and hypoxia. Oxidative stress is due to the excessive production of reactive oxygen species or diminished antioxidant defenses. Genetic variants, such as single nucleotide polymorphisms in antioxidant defense system genes, could alter the efficacy of these enzymes and, ultimately, the risk of obesity; thus, studies investigating the role of genetic variations in genes related to oxidative stress could be useful for better understanding the etiology of obesity and its metabolic complications. The lack of existing literature reviews in this field encouraged us to gather the findings from studies focusing on the impact of single nucleotide polymorphisms in antioxidant enzymes, oxidative stress-producing systems and transcription factor genes concerning their association with obesity risk and its phenotypes. In the future, the characterization of these single nucleotide polymorphisms (SNPs) in obese patients could contribute to the development of controlled antioxidant therapies potentially beneficial for the treatment of obesity-derived metabolic complications.
Keywords: polymorphism; oxidative stress; reactive oxygen species; antioxidant enzymes; obesity polymorphism; oxidative stress; reactive oxygen species; antioxidant enzymes; obesity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rupérez, A.I.; Gil, A.; Aguilera, C.M. Genetics of Oxidative Stress in Obesity. Int. J. Mol. Sci. 2014, 15, 3118-3144.

AMA Style

Rupérez AI, Gil A, Aguilera CM. Genetics of Oxidative Stress in Obesity. International Journal of Molecular Sciences. 2014; 15(2):3118-3144.

Chicago/Turabian Style

Rupérez, Azahara I.; Gil, Angel; Aguilera, Concepción M. 2014. "Genetics of Oxidative Stress in Obesity." Int. J. Mol. Sci. 15, no. 2: 3118-3144.


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