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Int. J. Mol. Sci. 2014, 15(2), 2119-2129; doi:10.3390/ijms15022119
Review

Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease

1
, 1
, 1
 and 1,2,*
Received: 27 November 2013; in revised form: 20 January 2014 / Accepted: 21 January 2014 / Published: 29 January 2014
(This article belongs to the Special Issue Neuroprotective Strategies 2014)
View Full-Text   |   Download PDF [640 KB, uploaded 19 June 2014]
Abstract: Alzheimer’s disease (AD) is the most common form of dementia, characterized by a decline in memory and cognitive function. Clinical manifestations of AD are closely associated with the formation of senile plaques and neurofibrillary tangles, neuronal loss and cognitive decline. Apoptosis signal regulating kinase 1 (ASK1) is a mediator of the MAPK pathway, which regulates various cellular responses such as apoptosis, cell survival, and differentiation. Accumulating evidence indicates that ASK1 plays a key role in the pathogenesis of neurodegenerative disorders such as Huntington’s disease and AD. Of particular interest, ASK1 is associated with many signaling pathways, which include endoplasmic reticulum (ER) stress-mediated apoptosis, Aβ-induced neurotoxicity, tau protein phosphorylation, and insulin signal transduction. Here, we review experimental evidence that links ASK1 signaling and AD pathogenesis and propose that ASK1 might be a new point of therapeutic intervention to prevent or treat AD.
Keywords: apoptosis signal regulating kinase 1 (ASK1); Alzheimer’s disease (AD); oxidative stress; endoplasmic reticulum (ER) stress; Aβ neurotoxicity; tau protein phosphorylation; insulin signal transduction apoptosis signal regulating kinase 1 (ASK1); Alzheimer’s disease (AD); oxidative stress; endoplasmic reticulum (ER) stress; Aβ neurotoxicity; tau protein phosphorylation; insulin signal transduction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Song, J.; Park, K.A.; Lee, W.T.; Lee, J.E. Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease. Int. J. Mol. Sci. 2014, 15, 2119-2129.

AMA Style

Song J, Park KA, Lee WT, Lee JE. Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease. International Journal of Molecular Sciences. 2014; 15(2):2119-2129.

Chicago/Turabian Style

Song, Juhyun; Park, Kyung A.; Lee, Won T.; Lee, Jong E. 2014. "Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s Disease." Int. J. Mol. Sci. 15, no. 2: 2119-2129.


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