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Molecular Motors and Apical CFTR Traffic in Epithelia
Department of Pediatrics/Gastroenterology & Hepatology, School of Medicine, Yale University, New Haven, CT 06520, USA
Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT 06520, USA
* Author to whom correspondence should be addressed.
Received: 7 April 2013; in revised form: 19 April 2013 / Accepted: 2 May 2013 / Published: 3 May 2013
Abstract: Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases.
Keywords: CFTR; trafficking; myosins; microtubules; actin transport
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Kravtsov, D.V.; Ameen, N.A. Molecular Motors and Apical CFTR Traffic in Epithelia. Int. J. Mol. Sci. 2013, 14, 9628-9642.
Kravtsov DV, Ameen NA. Molecular Motors and Apical CFTR Traffic in Epithelia. International Journal of Molecular Sciences. 2013; 14(5):9628-9642.
Kravtsov, Dmitri V.; Ameen, Nadia A. 2013. "Molecular Motors and Apical CFTR Traffic in Epithelia." Int. J. Mol. Sci. 14, no. 5: 9628-9642.