Int. J. Mol. Sci. 2013, 14(11), 23086-23102; doi:10.3390/ijms141123086
Review

Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

1,2,†email, 3,†email, 1email, 1email, 1email and 1,* email
Received: 24 September 2013; in revised form: 30 October 2013 / Accepted: 4 November 2013 / Published: 21 November 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
Keywords: let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker
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MDPI and ACS Style

Bao, M.-H.; Feng, X.; Zhang, Y.-W.; Lou, X.-Y.; Cheng, Y.; Zhou, H.-H. Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells. Int. J. Mol. Sci. 2013, 14, 23086-23102.

AMA Style

Bao M-H, Feng X, Zhang Y-W, Lou X-Y, Cheng Y, Zhou H-H. Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells. International Journal of Molecular Sciences. 2013; 14(11):23086-23102.

Chicago/Turabian Style

Bao, Mei-Hua; Feng, Xing; Zhang, Yi-Wen; Lou, Xiao-Ya; Cheng, Yu; Zhou, Hong-Hao. 2013. "Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells." Int. J. Mol. Sci. 14, no. 11: 23086-23102.

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