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Int. J. Mol. Sci. 2013, 14(11), 23086-23102; doi:10.3390/ijms141123086
Review

Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

1,2,†
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Received: 24 September 2013 / Revised: 30 October 2013 / Accepted: 4 November 2013 / Published: 21 November 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
Keywords: let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bao, M.-H.; Feng, X.; Zhang, Y.-W.; Lou, X.-Y.; Cheng, Y.; Zhou, H.-H. Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells. Int. J. Mol. Sci. 2013, 14, 23086-23102.

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