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Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells
Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
Department of Pharmacy, Changsha Medical University, Changsha 410219, China
College of Medicine, Hunan Normal University, Changsha 410006, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 September 2013; in revised form: 30 October 2013 / Accepted: 4 November 2013 / Published: 21 November 2013
Abstract: The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
Keywords: let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker
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Cite This Article
MDPI and ACS Style
Bao, M.-H.; Feng, X.; Zhang, Y.-W.; Lou, X.-Y.; Cheng, Y.; Zhou, H.-H. Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells. Int. J. Mol. Sci. 2013, 14, 23086-23102.
Bao M-H, Feng X, Zhang Y-W, Lou X-Y, Cheng Y, Zhou H-H. Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells. International Journal of Molecular Sciences. 2013; 14(11):23086-23102.
Bao, Mei-Hua; Feng, Xing; Zhang, Yi-Wen; Lou, Xiao-Ya; Cheng, Yu; Zhou, Hong-Hao. 2013. "Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells." Int. J. Mol. Sci. 14, no. 11: 23086-23102.