Open AccessThis article is
- freely available
Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan
Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Department of Pharmacy, China Medical University, Taichung 40402, Taiwan
Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 12 November 2012; in revised form: 11 December 2012 / Accepted: 17 December 2012 / Published: 27 December 2012
Abstract: Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
Keywords: Andrographis echioides; flavonoid; anti-inflammatory; iNOS
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Shen, D.-Y.; Juang, S.-H.; Kuo, P.-C.; Huang, G.-J.; Chan, Y.-Y.; Damu, A.G.; Wu, T.-S. Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. Int. J. Mol. Sci. 2013, 14, 496-514.
Shen D-Y, Juang S-H, Kuo P-C, Huang G-J, Chan Y-Y, Damu AG, Wu T-S. Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. International Journal of Molecular Sciences. 2013; 14(1):496-514.
Shen, De-Yang; Juang, Shin-Hun; Kuo, Ping-Chung; Huang, Guan-Jhong; Chan, Yu-Yi; Damu, Amooru G.; Wu, Tian-Shung. 2013. "Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity." Int. J. Mol. Sci. 14, no. 1: 496-514.