Next Article in Journal
IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain
Next Article in Special Issue
Enhancement of Palmarumycins C12 and C13 Production in Liquid Culture of Endophytic Fungus Berkleasmium sp. Dzf12 after Treatments with Metal Ions
Previous Article in Journal
Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region
Previous Article in Special Issue
Apoptosis Induction of Human Prostate Carcinoma DU145 Cells by Diallyl Disulfide via Modulation of JNK and PI3K/AKT Signaling Pathways
Int. J. Mol. Sci. 2013, 14(1), 496-514; doi:10.3390/ijms14010496

Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

Received: 12 November 2012 / Revised: 11 December 2012 / Accepted: 17 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2012)
View Full-Text   |   Download PDF [341 KB, 19 June 2014; original version 19 June 2014]   |   Browse Figures


Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (12) and (619) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
Keywords: Andrographis echioides; flavonoid; anti-inflammatory; iNOS Andrographis echioides; flavonoid; anti-inflammatory; iNOS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Shen, D.-Y.; Juang, S.-H.; Kuo, P.-C.; Huang, G.-J.; Chan, Y.-Y.; Damu, A.G.; Wu, T.-S. Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity. Int. J. Mol. Sci. 2013, 14, 496-514.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert