Int. J. Mol. Sci. 2012, 13(6), 7739-7761; doi:10.3390/ijms13067739
Review

Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke

Kiyoshi Kikuchi 1,2 email, Hisaaki Uchikado 2,3 email, Motohiro Morioka 2 email, Yoshinaka Murai 1 email and Eiichiro Tanaka 1,* email
1 Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan 2 Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan 3 Uchikado Neuro-Spine Clinic, 1-2-3 Naka, Hakata-ku, Fukuoka 812-0893, Japan
* Author to whom correspondence should be addressed.
Received: 15 May 2012; in revised form: 15 June 2012 / Accepted: 19 June 2012 / Published: 21 June 2012
(This article belongs to the Special Issue Neuroprotective Strategies 2012)
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Abstract: Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy.
Keywords: stroke; neuroprotective effect; clinical drugs

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MDPI and ACS Style

Kikuchi, K.; Uchikado, H.; Morioka, M.; Murai, Y.; Tanaka, E. Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke. Int. J. Mol. Sci. 2012, 13, 7739-7761.

AMA Style

Kikuchi K, Uchikado H, Morioka M, Murai Y, Tanaka E. Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke. International Journal of Molecular Sciences. 2012; 13(6):7739-7761.

Chicago/Turabian Style

Kikuchi, Kiyoshi; Uchikado, Hisaaki; Morioka, Motohiro; Murai, Yoshinaka; Tanaka, Eiichiro. 2012. "Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke." Int. J. Mol. Sci. 13, no. 6: 7739-7761.

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