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Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke
Int. J. Mol. Sci. 2012, 13(6), 7739-7761; doi:10.3390/ijms13067739

Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke

1 Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan 2 Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan 3 Uchikado Neuro-Spine Clinic, 1-2-3 Naka, Hakata-ku, Fukuoka 812-0893, Japan
* Author to whom correspondence should be addressed.
Received: 15 May 2012 / Revised: 15 June 2012 / Accepted: 19 June 2012 / Published: 21 June 2012
(This article belongs to the Special Issue Neuroprotective Strategies 2012)
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Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy.
Keywords: stroke; neuroprotective effect; clinical drugs stroke; neuroprotective effect; clinical drugs
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kikuchi, K.; Uchikado, H.; Morioka, M.; Murai, Y.; Tanaka, E. Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke. Int. J. Mol. Sci. 2012, 13, 7739-7761.

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