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Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
Uchikado Neuro-Spine Clinic, 1-2-3 Naka, Hakata-ku, Fukuoka 812-0893, Japan
* Author to whom correspondence should be addressed.
Received: 15 May 2012; in revised form: 15 June 2012 / Accepted: 19 June 2012 / Published: 21 June 2012
Abstract: Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy.
Keywords: stroke; neuroprotective effect; clinical drugs
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Kikuchi, K.; Uchikado, H.; Morioka, M.; Murai, Y.; Tanaka, E. Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke. Int. J. Mol. Sci. 2012, 13, 7739-7761.
Kikuchi K, Uchikado H, Morioka M, Murai Y, Tanaka E. Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke. International Journal of Molecular Sciences. 2012; 13(6):7739-7761.
Kikuchi, Kiyoshi; Uchikado, Hisaaki; Morioka, Motohiro; Murai, Yoshinaka; Tanaka, Eiichiro. 2012. "Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke." Int. J. Mol. Sci. 13, no. 6: 7739-7761.