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• Tamas, A
• Reglodi, D
• Farkas, O
• Kovesdi, E
• Pal, J
• Povlishock, J
• Schwarcz, A
• Czeiter, E
• Szanto, Z
• Doczi, T
• Buki, A
• Bukovics, P
• [+] on Google Scholar
• Tamas, A
• Reglodi, D
• Farkas, O
• Kovesdi, E
• Pal, J
• Povlishock, J
• Schwarcz, A
• Czeiter, E
• Szanto, Z
• Doczi, T
• Buki, A
• Bukovics, P
• [+] on PubMed
• Tamas, A
• Reglodi, D
• Farkas, O
• Kovesdi, E
• Pal, J
• Povlishock, J
• Schwarcz, A
• Czeiter, E
• Szanto, Z
• Doczi, T
• Buki, A
• Bukovics, P

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Int. J. Mol. Sci. 2012, 13(7), 8430-8448; doi:10.3390/ijms13078430

Review

Effect of PACAP in Central and Peripheral Nerve Injuries

Andrea Tamas ^1,* , Dora Reglodi ¹ , Orsolya Farkas ² , Erzsebet Kovesdi ² , Jozsef Pal ² , John T. Povlishock ³ , Attila Schwarcz ² , Endre Czeiter ^1,2 , Zalan Szanto ⁴ , Tamas Doczi ² , Andras Buki ^2,†  and Peter Bukovics ^2,†

¹ PTE-MTA “Lendulet” PACAP Research Team, Department of Anatomy, University of Pecs, Szigeti. u. 12, H-7624 Pecs, Hungary ² MTA-PTE Clinical Neuroscience MR Research Group, Department of Neurosurgery, University of Pecs, Ret u. 2, H-7623 Pecs, Hungary ³ Department of Anatomy and Neurobiology, Virginia Commonwealth University, 1101 E. Marshall Street Richmond, Richmond, VA 23219, USA ⁴ Department of Surgery, Medical School, University of Pecs, Ret u. 2., H-7623 Pecs, Hungary ^† These authors contributed equally to the present work.

* Author to whom correspondence should be addressed.

Received: 11 May 2012; in revised form: 25 June 2012 / Accepted: 26 June 2012 / Published: 6 July 2012

(This article belongs to the Special Issue Neuroprotective Strategies 2012)

Download PDF Full-Text [145 KB, uploaded 6 July 2012 13:17 CEST]

Abstract: Pituitary adenylate cyclase activating polypeptide (PACAP) is a bioactive peptide with diverse effects in the nervous system. In addition to its more classic role as a neuromodulator, PACAP functions as a neurotrophic factor. Several neurotrophic factors have been shown to play an important role in the endogenous response following both cerebral ischemia and traumatic brain injury and to be effective when given exogenously. A number of studies have shown the neuroprotective effect of PACAP in different models of ischemia, neurodegenerative diseases and retinal degeneration. The aim of this review is to summarize the findings on the neuroprotective potential of PACAP in models of different traumatic nerve injuries. Expression of endogenous PACAP and its specific PAC1 receptor is elevated in different parts of the central and peripheral nervous system after traumatic injuries. Some experiments demonstrate the protective effect of exogenous PACAP treatment in different traumatic brain injury models, in facial nerve and optic nerve trauma. The upregulation of endogenous PACAP and its receptors and the protective effect of exogenous PACAP after different central and peripheral nerve injuries show the important function of PACAP in neuronal regeneration indicating that PACAP may also be a promising therapeutic agent in injuries of the nervous system.

Keywords: endogenous; injury; neuroprotection; pituitary adenylate cyclase activating polypeptide; trauma

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