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• Sirko, A
• Vaněk, T
• Góra-Sochacka, A
• Redkiewicz, P
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• Sirko, A
• Vaněk, T
• Góra-Sochacka, A
• Redkiewicz, P
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• Sirko, A
• Vaněk, T
• Góra-Sochacka, A
• Redkiewicz, P

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Int. J. Mol. Sci. 2011, 12(6), 3536-3552; doi:10.3390/ijms12063536

Review

Recombinant Cytokines from Plants

Agnieszka Sirko ^1,* , Tomas Vaněk ², Anna Góra-Sochacka ¹ and Patrycja Redkiewicz ¹

¹ Institute of Biochemistry and Biophysics Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland ² Laboratory of Plant Biotechnologies, Joint Laboratory of Institute of Experimental Botany and Institute of Crop Research, Prague, Czech Republic

* Author to whom correspondence should be addressed.

Received: 31 March 2011; in revised form: 11 May 2011 / Accepted: 27 May 2011 / Published: 3 June 2011

(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming)

Download PDF Full-Text [337 KB, uploaded 3 June 2011 11:05 CEST]

Abstract: Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.

Keywords: cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants

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