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Evolution of Plant-Made Pharmaceuticals
Int. J. Mol. Sci. 2011, 12(6), 3536-3552; doi:10.3390/ijms12063536
Review

Recombinant Cytokines from Plants

1,* , 2
,
1
 and
1
1 Institute of Biochemistry and Biophysics Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland 2 Laboratory of Plant Biotechnologies, Joint Laboratory of Institute of Experimental Botany and Institute of Crop Research, Prague, Czech Republic
* Author to whom correspondence should be addressed.
Received: 31 March 2011 / Revised: 11 May 2011 / Accepted: 27 May 2011 / Published: 3 June 2011
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming)
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Abstract

Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
Keywords: cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sirko, A.; Vaněk, T.; Góra-Sochacka, A.; Redkiewicz, P. Recombinant Cytokines from Plants. Int. J. Mol. Sci. 2011, 12, 3536-3552.

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