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Int. J. Mol. Sci. 2011, 12(6), 3536-3552; doi:10.3390/ijms12063536
Review

Recombinant Cytokines from Plants

1,* email, 2email, 1email and 1email
Received: 31 March 2011; in revised form: 11 May 2011 / Accepted: 27 May 2011 / Published: 3 June 2011
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
Keywords: cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants
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MDPI and ACS Style

Sirko, A.; Vaněk, T.; Góra-Sochacka, A.; Redkiewicz, P. Recombinant Cytokines from Plants. Int. J. Mol. Sci. 2011, 12, 3536-3552.

AMA Style

Sirko A, Vaněk T, Góra-Sochacka A, Redkiewicz P. Recombinant Cytokines from Plants. International Journal of Molecular Sciences. 2011; 12(6):3536-3552.

Chicago/Turabian Style

Sirko, Agnieszka; Vaněk, Tomas; Góra-Sochacka, Anna; Redkiewicz, Patrycja. 2011. "Recombinant Cytokines from Plants." Int. J. Mol. Sci. 12, no. 6: 3536-3552.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert