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Molecules, Volume 4, Issue 12 (December 1999), Pages 338-372, Articles M125-M126

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Open AccessArticle X-Ray Crystal Structure of 10β-Hydroxy-4β,5β-epoxyestr-1-en-3,17-dione and Antitumor Activity of its Congeners
Molecules 1999, 4(12), 338-352; doi:10.3390/41200338
Received: 5 August 1999 / Accepted: 1 November 1999 / Published: 23 November 1999
Cited by 6 | PDF Full-text (221 KB)
Abstract
Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules [...] Read more.
Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed structure was established by X-ray analysis revealing two symmetry independent molecules in the asymmetric unit each consisting of four fused rings with the C(10) β-oriented hydroxy group and β-oriented O atom bridging C(4) and C(5). The conformation of A ring in both conformers A and B is boat (B3,6), while rings B and C are chairs (1C4) and the five-membered D ring is in an envelope (E2) conformation. The in vitro antitumor activity of title compound and its 17b-acetoxy analogue against HeLa and Fem-x cells revealed IC50 values of 5.7 and 7.1 mM, and 2.25 and 1.58 mM, respectively. Corresponding quinols were tested on 47 cell lines with 10b-hydroxy-17β-acetoxyestra-1,4-dien-3-one being most active against leukemia SR cells (GI50 = 0.17 mM). Full article
Open AccessArticle Teaching NMR Using Online Textbooks
Molecules 1999, 4(12), 353-365; doi:10.3390/41200353
Received: 30 September 1999 / Accepted: 30 November 1999 / Published: 1 December 1999
PDF Full-text (83 KB)
Abstract
Nuclear magnetic resonance (NMR) spectroscopy has almost become an essential analytical tool for the chemist. High-resolution one- and multi-dimensional NMR, timedomain NMR, and NMR microscopy are but a few of the NMR techniques at a chemist's disposal to determine chemical structure and [...] Read more.
Nuclear magnetic resonance (NMR) spectroscopy has almost become an essential analytical tool for the chemist. High-resolution one- and multi-dimensional NMR, timedomain NMR, and NMR microscopy are but a few of the NMR techniques at a chemist's disposal to determine chemical structure and dynamics. Consequently, even small chemistry departments are finding it necessary to provide students with NMR training and experience in at least some of these techniques. The hands-on experience is readily provided with access to state-of-the-art commercial spectrometers. Instruction in the principles of NMR is more difficult to achieve as most instructors try to teach NMR using single organic or analytical chemistry book chapters with static figures. This paper describes an online textbook on NMR spectroscopy called The Basics of NMR (http://www.cis.rit.edu/htbooks/nmr/) suitable for use in teaching the principles of NMR spectroscopy. The book utilizes hypertext and animations to present the principles of NMR spectroscopy. The book can be used as a textbook associated with a lecture or as a stand-alone teaching tool. Conference participants are encouraged to review the textbook and evaluate its suitability for us in teaching NMR spectroscopy to undergraduate chemistry majors. Full article

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Open AccessShort Note 6-Methyl-3-nitroso-1-phenethyl-4-(phenethylamino)-2(1H)-pyridinone
Molecules 1999, 4(12), M125; doi:10.3390/M125
Received: 13 December 1999 / Accepted: 14 December 1999 / Published: 17 December 1999
PDF Full-text (91 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note N-{2-[(2-Oxo-2H-chromen-4-yl)amino]ethyl}acetamide
Molecules 1999, 4(12), M126; doi:10.3390/M126
Received: 6 November 1999 / Accepted: 24 November 1999 / Published: 17 December 1999
Cited by 1 | PDF Full-text (96 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessBook Review Molecular Catenanes, Rotaxanes and Knots. A Journey Through the World of Molecular Topology. Edited by J.-P. Sauvage
Molecules 1999, 4(12), 366-367; doi:10.3390/41200366
Received: 28 October 1999 / Published: 31 December 1999
PDF Full-text (6 KB)
Open AccessBook Review Ullmann’s Encyclopedia of Industrial Chemistry. CD-ROM. 6th Edition 1999 Electronic Release
Molecules 1999, 4(12), 368-370; doi:10.3390/41200368
Received: 6 December 1999 / Published: 31 December 1999
PDF Full-text (8 KB)
Open AccessBook Review Industrial Organic Chemicals. Starting Materials and Intermediates
Molecules 1999, 4(12), 371-372; doi:10.3390/41200371
Received: 7 December 1999 / Published: 31 December 1999
PDF Full-text (5 KB)

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