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Molecules, Volume 28, Issue 8

2023 April-2 - 363 articles

Cover Story: G-quadruplexes are secondary structures of guanine-rich DNA sequences, believed to be associated with gene regulation in the promoter region during transcription. Of particular interest is the formation of such structures in the insulin-linked polymorphic region (ILPR). Through the design of ligands binding to (and thus stabilising) such G-quadruplexes, it might eventually be possible to regulate insulin production, opening new avenues for therapeutic diabetes treatment. Adapting a protocol based on free-energy molecular dynamics simulations, we have computed the binding affinity of porphyrin-based ligands to a suitable ILPR model. Special attention is called to the effect of flexible polyether side chains that can nestle into the grooves of the G-quadruplex structure, thereby increasing the free energy of binding noticeably. View this paper
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Articles (363)

  • Article
  • Open Access
1 Citations
2,152 Views
13 Pages

21 April 2023

Modern computational protocols based on the density functional theory (DFT) infer that polyhedral closo ten-vertex carboranes are key starting stationary states in obtaining ten-vertex cationic carboranes. The rearrangement of the bicapped square pol...

(This article belongs to the Special Issue New Developments in Boron Chemistry: From Oxidoborates to Hydrido(hetero)borane Derivatives – in Celebration of Professor John D. Kennedy’s 80th Birthday)
  • Article
  • Open Access
7 Citations
3,719 Views
13 Pages

21 April 2023

In this study, we report the synthesis, characterization, and reactions of Cu(I) complexes of the general form Cu(L)(LigH2) (LigH2 = xanthene-based heterodinucleating ligand (E)-3-(((5-(bis(pyridin-2-ylmethyl)amino)-2,7-di-tert-butyl-9,9-dimethyl-9H-...

(This article belongs to the Special Issue Molybdenum and Tungsten Enzymes—State of the Art in Research)
  • Article
  • Open Access
23 Citations
5,376 Views
25 Pages

Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan

  • Hossam S. El-Beltagi,
  • Salwa M. El-Sayed,
  • Ahmed. N. Abdelhamid,
  • Karim. M. Hassan,
  • Walaa. A. Elshalakany,
  • Mona Ibrahim Nossier,
  • Nadiyah M. Alabdallah,
  • Nadi Awad Al-Harbi,
  • Salem Mesfir Al-Qahtani and
  • Hemmat A. Ibrahim
  • + 2 authors

21 April 2023

Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
4 Citations
3,291 Views
12 Pages

Trametes hirsuta as an Attractive Biocatalyst for the Preparative Scale Biotransformation of Isosafrole into Piperonal

  • Dawid Hernik,
  • Ewa Szczepańska,
  • Elisabetta Brenna,
  • Katarzyna Patejuk,
  • Teresa Olejniczak,
  • Tomasz Strzała and
  • Filip Boratyński

21 April 2023

Piperonal is a compound of key industrial importance due to its attractive olfactory and biological properties. It has been shown that among the fifty-six various fungal strains tested, the ability to cleave the toxic isosafrole into piperonal throug...

(This article belongs to the Special Issue Bioelements and Bioactive Metabolites of Natural Origin—Health-Promoting Applications)
  • Review
  • Open Access
171 Citations
28,174 Views
16 Pages

21 April 2023

Insecticides play a critical role in controlling the spread of insect-borne diseases and preserving crop health. These chemical substances are specifically formulated to kill or manage insect populations. Over the years, various types of insecticides...

(This article belongs to the Special Issue Novel Targets in Pest Control: Molecular Characterization, Structural and Biochemical Properties, Physiological Functions, and Evolution)
  • Article
  • Open Access
29 Citations
5,198 Views
17 Pages

Preparation of Multifunctional Surfactants Derived from Sodium Dodecylbenzene Sulfonate and Their Use in Oil-Field Chemistry

  • Yongfei Li,
  • Quanzheng Bai,
  • Qiang Li,
  • Hai Huang,
  • Weijun Ni,
  • Qian Wang,
  • Xin Xin,
  • Bin Zhao and
  • Gang Chen

21 April 2023

Four products were obtained from sodium dodecylbenzene sulfonate (SDBS) and formaldehyde (40% solution) using a simple reaction. The products were characterized by TGA, IR, UV and MS to confirm the major chemicals in each sample. The new products cou...

  • Feature Paper
  • Review
  • Open Access
13 Citations
10,586 Views
30 Pages

Biological Potential of Carnivorous Plants from Nepenthales

  • Magdalena Wójciak,
  • Marcin Feldo,
  • Piotr Stolarczyk and
  • Bartosz J. Płachno

21 April 2023

Since Charles Darwin and his book carnivorous plants have aroused interest and heated debate. In addition, there is growing interest in this group of plants as a source of secondary metabolites and in the application of their biological activity. The...

(This article belongs to the Special Issue Medicinal Value of Natural Bioactive Compounds and Plant Extracts)
  • Article
  • Open Access
11 Citations
3,721 Views
17 Pages

Rapid Assembly of Pyrrole-Ligated 1,3,4-Oxadiazoles and Excellent Antibacterial Activity of Iodophenol Substituents

  • Hyein Kim,
  • Lina Gu,
  • Huisu Yeo,
  • Umji Choi,
  • Chang-Ro Lee,
  • Haiyang Yu and
  • Sangho Koo

21 April 2023

Pyrrole-ligated 1,3,4-oxadiazole is a very important pharmacophore which exhibits broad therapeutic effects such as anti-tuberculosis, anti-epileptic, anti-HIV, anti-cancer, anti-inflammatory, antioxidant, and antibacterial activities. A one-pot Mail...

(This article belongs to the Special Issue Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles)
  • Article
  • Open Access
17 Citations
3,615 Views
12 Pages

A Novel Non-Metallic Photocatalyst: Phosphorus-Doped Sulfur Quantum Dots

  • Ziyi Liu,
  • Chuanfu Shan,
  • Guiyu Wei,
  • Jianfeng Wen,
  • Li Jiang,
  • Guanghui Hu,
  • Zhijie Fang,
  • Tao Tang and
  • Ming Li

21 April 2023

In this paper, a novel phosphorus-doped sulfur quantum dots (P-SQDs) material was prepared using a simple hydrothermal method. P-SQDs have a narrow particle size distribution as well as an excellent electron transfer rate and optical properties. Comp...

(This article belongs to the Special Issue Wastewater Treatment: Functional Materials and Advanced Technology)
  • Article
  • Open Access
10 Citations
2,924 Views
16 Pages

21 April 2023

The popularity of plant food supplements has seen explosive growth all over the world, making them susceptible to adulteration and fraud. This necessitates a screening approach for the detection of regulated plants in plant food supplements, which ar...

(This article belongs to the Section Analytical Chemistry)
  • Review
  • Open Access
38 Citations
7,038 Views
20 Pages

21 April 2023

Senkyunolide I (SI) is a natural phthalide that has drawn increasing interest for its potential as a cardio-cerebral vascular drug candidate. In this paper, the botanical sources, phytochemical characteristics, chemical and biological transformations...

(This article belongs to the Section Natural Products Chemistry)
  • Review
  • Open Access
27 Citations
9,548 Views
22 Pages

21 April 2023

Heme b, which is characterized by a ferrous ion and a porphyrin macrocycle, acts as a prosthetic group for many enzymes and contributes to various physiological processes. Consequently, it has wide applications in medicine, food, chemical production,...

(This article belongs to the Special Issue Microbial Synthesis of Polymers and Polymer Precursors)
  • Article
  • Open Access
13 Citations
3,920 Views
20 Pages

Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking

  • Tian-Meng Cui,
  • Muhammad Altaf,
  • Abdu Aldarhami,
  • Abdulrahman S. Bazaid,
  • Nizar H. Saeedi,
  • Almohanad A. Alkayyal,
  • Fahad M. Alshabrmi,
  • Farman Ali,
  • Mohammed Aladhadh and
  • Yue-Rong Ma
  • + 2 authors

21 April 2023

Overexpression of the thymidine phosphorylase (TP) enzyme induces angiogenesis, which eventually leads to metastasis and tumor growth. The crucial role of TP in cancer development makes it an important target for anticancer drug discovery. Currently,...

(This article belongs to the Special Issue Five and Six-Membered Heterocyclic Compounds and Their Therapeutic Potential)
  • Article
  • Open Access
15 Citations
3,587 Views
15 Pages

Rapid Detection of Cd2+ Ions in the Aqueous Medium Using a Highly Sensitive and Selective Turn-On Fluorescent Chemosensor

  • Maria Sadia,
  • Jehangir Khan,
  • Rizwan Khan,
  • Abdul Waheed Kamran,
  • Muhammad Zahoor,
  • Riaz Ullah,
  • Ahmed Bari and
  • Essam A. Ali

21 April 2023

Herein, a novel optical chemosensor, (CM1 = 2, 6-di((E)-benzylidene)-4-methylcyclohexan-1-one), was designed/synthesized and characterized by 1H-NMR and FT-IR spectroscopy. The experimental observations indicated that CM1 is an efficient and selectiv...

(This article belongs to the Section Analytical Chemistry)
  • Article
  • Open Access
12 Citations
3,266 Views
15 Pages

21 April 2023

The synthesis, sensor activity, and logic behavior of a novel 4-iminoamido-1,8-naphthalimide bichromophoric system based on a “fluorophore-receptor” architecture with ICT chemosensing properties is reported. The synthesized compound showe...

(This article belongs to the Special Issue Exclusive Feature Papers in Physical Chemistry)
  • Article
  • Open Access
24 Citations
3,862 Views
14 Pages

Salvianolic Acid A Improves Rat Kidney Injury by Regulating MAPKs and TGF-β1/Smads Signaling Pathways

  • Hai-Yang Diao,
  • Wei Zhu,
  • Jie Liu,
  • Sheng Yin,
  • Jin-Hui Wang and
  • Chun-Li Li

21 April 2023

Salvianolic acid A (SAA) is one of the major components in Salvia miltiorrhiza Bge., with various pharmacological activities, and is likely to be a promising agent for the treatment of kidney diseases. The purpose of this study was to explore the pro...

(This article belongs to the Special Issue Study on Chemical Constituents and Pharmacological Action of Natural Medicines)
  • Feature Paper
  • Article
  • Open Access
5 Citations
4,765 Views
19 Pages

Identification of Protein Quality Markers in Toad Venom from Bufo gargarizans

  • Meiyun Yang,
  • Weiwei Huan,
  • Guobing Zhang,
  • Jie Li,
  • Fengyan Xia,
  • Rabia Durrani,
  • Wei Zhao,
  • Jidong Lu,
  • Xinmeng Peng and
  • Fei Gao

21 April 2023

Toad venom is a traditional Chinese medicine with high medicinal value. The existing quality evaluation standards of toad venom have obvious limitations because of the lack of research on proteins. Thus, it is necessary to screen suitable quality mar...

(This article belongs to the Special Issue Mass Spectrometry in Biomarkers Discovery)
  • Article
  • Open Access
5 Citations
3,012 Views
12 Pages

Experimental and Simulation Studies on Hematite Interaction with Na-Metasilicate Pentahydrate

  • Gonzalo R. Quezada,
  • Norman Toro,
  • R. S. Krishna,
  • Subhabrata Mishra,
  • Pedro Robles,
  • Ivan Salazar,
  • Enoque Mathe and
  • Ricardo I. Jeldres

21 April 2023

Iron ore is a fundamental pillar in construction globally, however, its process is highly polluting and deposits are becoming less concentrated, making reusing or reprocessing its sources a sustainable solution to the current industry. A rheological...

(This article belongs to the Section Computational and Theoretical Chemistry)
  • Article
  • Open Access
12 Citations
3,659 Views
12 Pages

21 April 2023

Due to its poor toughness and hydrophilicity, the application of polylactic acid (PLA) in the field of absorbent sanitary materials is restricted. A butenediol vinyl alcohol copolymer (BVOH) was used to improve PLA via melt blending. The morphology,...

(This article belongs to the Section Macromolecular Chemistry)
  • Article
  • Open Access
31 Citations
3,902 Views
24 Pages

Designing Electron-Deficient Diketone Unit Based Non-Fused Ring Acceptors with Amplified Optoelectronic Features for Highly Efficient Organic Solar Cells: A DFT Study

  • Muhammad Usman Khan,
  • Faiza Shafiq,
  • Sanaa S. Al Abbad,
  • Junaid Yaqoob,
  • Riaz Hussain,
  • Zainab H. A. Alsunaidi,
  • Ghulam Mustafa and
  • Shabbir Hussain

21 April 2023

Organic solar cells (OSCs) made of electron-acceptor and electron-donor materials have significantly developed in the last decade, demonstrating their enormous potential in cutting-edge optoelectronic applications. Consequently, we designed seven nov...

(This article belongs to the Special Issue Recent Advancements in Density Functional Theory (DFT) and beyond for Computational Chemistry)
  • Article
  • Open Access
5 Citations
3,459 Views
12 Pages

Study of the Properties of CdS:Al (R = [Al3+]/[Cd2+] = 0.30, 0.40, 0.50) Thin Films Grown by the CBD Method in an Ammonia-Free System

  • Raju Prasanna-Kumari,
  • Daniela Herrera-Molina,
  • Arturo Fernández-Pérez,
  • Jesús E. Diosa and
  • Edgar Mosquera-Vargas

21 April 2023

CdS:Al thin films were fabricated on a glass substrate using the CBD method. The effect of aluminum incorporation on the structural, morphological, vibrational, and optical properties of CdS thin layers was investigated by X-ray diffraction (XRD), Ra...

(This article belongs to the Special Issue 2D Nanomaterials and Composites for Energy and Environmental Sustainability)
  • Review
  • Open Access
24 Citations
6,680 Views
19 Pages

Perhexiline: Old Drug, New Tricks? A Summary of Its Anti-Cancer Effects

  • Bimala Dhakal,
  • Yoko Tomita,
  • Paul Drew,
  • Timothy Price,
  • Guy Maddern,
  • Eric Smith and
  • Kevin Fenix

21 April 2023

Cancer metabolic plasticity, including changes in fatty acid metabolism utilisation, is now widely appreciated as a key driver for cancer cell growth, survival and malignancy. Hence, cancer metabolic pathways have been the focus of much recent drug d...

(This article belongs to the Collection Efficient Pharmaceutical and Chemical Approaches for Anticancer Therapy: Design, Preliminary Evaluations, and Further Developments)
  • Article
  • Open Access
6 Citations
4,199 Views
13 Pages

Phytoestrogens as Biomarkers of Plant Raw Materials Used for Fish Feed Production

  • Dionysios T. Pavlopoulos,
  • Eleni D. Myrtsi,
  • Paschalitsa Tryfinopoulou,
  • Vasilios Iliopoulos,
  • Sofia D. Koulocheri and
  • Serkos A. Haroutounian

21 April 2023

The intensive use of plant materials as a sustainable alternative for fish feed production, combined with their phytochemical content, which affects the growth and production characteristics of farmed fishes, necessitates their monitoring for the pre...

(This article belongs to the Section Natural Products Chemistry)
  • Review
  • Open Access
66 Citations
11,758 Views
22 Pages

Synthesis and Peroxide Activation Mechanism of Bimetallic MOF for Water Contaminant Degradation: A Review

  • Mengke Fan,
  • Jingwei Yan,
  • Quantao Cui,
  • Run Shang,
  • Qiting Zuo,
  • Lin Gong and
  • Wei Zhang

21 April 2023

Metal–organic framework (MOF) materials possess a large specific surface area, high porosity, and atomically dispersed metal active sites, which confer excellent catalytic performance as peroxide (peroxodisulfate (PDS), peroxomonosulfate (PMS),...

  • Article
  • Open Access
4 Citations
2,787 Views
14 Pages

21 April 2023

A combination of the peroxymonosulfate (PMS) electro-activation process and the electro-oxidation process driven by a pulsed electric field (PEF) was used to degrade sulfadiazine (SND) wastewater. Mass transfer is the limiting step of electrochemical...

  • Article
  • Open Access
10 Citations
6,387 Views
15 Pages

Isomers of the Tomato Glycoalkaloids α-Tomatine and Dehydrotomatine: Relationship to Health Benefits

  • Nobuyuki Kozukue,
  • Dong-Seok Kim,
  • Suk-Hyun Choi,
  • Masashi Mizuno and
  • Mendel Friedman

21 April 2023

High-performance liquid chromatography (HPLC) analysis of three commercial tomatine samples and another isolated from green tomatoes revealed the presence of two small peaks in addition to those associated with the glycoalkaloids dehydrotomatine and...

(This article belongs to the Special Issue Application of Liquid Chromatography in Food and Natural Products Extracts Analysis)
  • Article
  • Open Access
5 Citations
2,506 Views
13 Pages

21 April 2023

Kaposi’s sarcoma, an AIDS-defining illness, is caused by Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus. In this study, we engineered ribozymes derived from ribonuclease P (RNase P) catalytic RNA with targeting against...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
19 Citations
5,865 Views
16 Pages

21 April 2023

Ionic liquids (ILs) have arisen as alternatives to organic solvents and been used in natural pigment extraction in recent decades. However, the solubility and stability of carotenoids in phosphonium- and ammonium-based ILs are insufficiently explored...

(This article belongs to the Special Issue Greener Ionic Liquids)
  • Article
  • Open Access
8 Citations
2,754 Views
16 Pages

21 April 2023

Refined and deodorized camellia oil has been reported to contain a high amount of 3-monochloropropane-1,2-diol esters (3-MCPDE) due to the high-temperature deodorization step. To reduce 3-MCPDE in camellia oil, the physical refining process of camell...

(This article belongs to the Section Food Chemistry)
  • Article
  • Open Access
3 Citations
2,914 Views
14 Pages

21 April 2023

Cerebrospinal fluid (CSF) proteins are very important because they can serve as biomarkers for central nervous system diseases. Although many CSF proteins have been identified with wet experiments, the identification of CSF proteins is still a challe...

(This article belongs to the Special Issue Mass Spectrometric Proteomics III)
  • Review
  • Open Access
22 Citations
11,443 Views
15 Pages

21 April 2023

KRAS gene mutation is widespread in tumors and plays an important role in various malignancies. Targeting KRAS mutations is regarded as the “holy grail” of targeted cancer therapies. Recently, multiple strategies, including covalent bindi...

(This article belongs to the Special Issue Recent Trends on Enzymes Inhibitors and Activators in Drug Research 3.0)
  • Article
  • Open Access
63 Citations
6,293 Views
15 Pages

Natural Deep Eutectic Solvents for the Extraction of Triterpene Saponins from Aralia elata var. mandshurica (Rupr. & Maxim.) J. Wen

  • Alyona A. Petrochenko,
  • Anastasia Orlova,
  • Nadezhda Frolova,
  • Evgeny B. Serebryakov,
  • Alena Soboleva,
  • Elena V. Flisyuk,
  • Andrej Frolov and
  • Alexander N. Shikov

21 April 2023

The roots of the medicinal plant Aralia elata are rich in biologically active natural products, with triterpene saponins constituting one of their major groups. These metabolites can be efficiently extracted by methanol and ethanol. Due to their low...

(This article belongs to the Section Analytical Chemistry)
  • Article
  • Open Access
6 Citations
3,566 Views
15 Pages

The Antibacterial Activity of Rhazya stricta Extracts against Klebsiella pneumoniae Isolated from Some Soil Invertebrates at High Altitudes

  • Mohamed M. Hassan,
  • Bander Albogami,
  • Tarombera Mwabvu,
  • Mohamed F. Awad,
  • Roqayah H. Kadi,
  • Alaa A. Mohamed,
  • Jamal A. Al-Orabi,
  • Montaser M. Hassan and
  • Mohsen Mohamed Elsharkawy

21 April 2023

Klebsiella is a common dangerous pathogen for humans and animals and is widely present in the digestive system. The genus Klebsiella is ubiquitous, as it is endemic to surface water, soil, and sewage. In this study, 70 samples were obtained from soil...

(This article belongs to the Special Issue Bioactive Plant Extracts for Pharmaceutical, Nutraceutical and Cosmetic Applications)
  • Article
  • Open Access
5 Citations
2,910 Views
38 Pages

21 April 2023

Globally, breast cancer is the most prevalent form of cancer in women and there is a need for alternative therapies such as plant-derived compounds with low systemic toxicity and selective toxicity to cancer cells. The aim of this study is to assess...

(This article belongs to the Special Issue The Functional Applications of Medicinal Plants)
  • Article
  • Open Access
3 Citations
3,695 Views
13 Pages

Monocyte Differentiation on Atomic Layer-Deposited (ALD) Hydroxyapatite Coating on Titanium Substrate

  • Elina Kylmäoja,
  • Faleh Abushahba,
  • Jani Holopainen,
  • Mikko Ritala and
  • Juha Tuukkanen

21 April 2023

Hydroxyapatite (HA; Ca10(PO4)6(OH)2) coating of bone implants has many beneficial properties as it improves osseointegration and eventually becomes degraded and replaced with new bone. We prepared HA coating on a titanium substrate with atomic layer...

(This article belongs to the Special Issue Biomaterials Based on Calcium Phosphates and Their Modifications)
  • Review
  • Open Access
42 Citations
10,874 Views
22 Pages

The Research Progress of Extraction, Purification and Analysis Methods of Phenolic Compounds from Blueberry: A Comprehensive Review

  • Xinyu Bai,
  • Lin Zhou,
  • Li Zhou,
  • Song Cang,
  • Yuhan Liu,
  • Rui Liu,
  • Jie Liu,
  • Xun Feng and
  • Ronghua Fan

21 April 2023

Blueberry is the source of a variety of bioactive substances, including phenolic compounds, such as anthocyanins, pterostilbene, phenolic acids, etc. Several studies have revealed that polyphenols in blueberry have important bioactivities in maintain...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
6 Citations
3,264 Views
14 Pages

Myo-Inositol, Scyllo-Inositol, and Other Minor Carbohydrates as Authenticity Markers for the Control of Italian Bulk, Concentrate, and Rectified Grape Must

  • Mauro Paolini,
  • Matteo Perini,
  • Letizia Allari,
  • Loris Tonidandel,
  • Fabio Finato,
  • Katia Guardini and
  • Roberto Larcher

20 April 2023

Myo-inositol polyalcohol is a characteristic component of natural and concentrated grape musts (CMs), and Regulation (EU) no. 1308/2013 prescribes its presence as a marker of the authenticity of rectified concentrated must (RCM). Other polyalcohols b...

(This article belongs to the Special Issue Analytical Chemistry in Europe: Towards Sustainability and Quality of Life)
  • Article
  • Open Access
3 Citations
3,166 Views
13 Pages

20 April 2023

The first three compounds based on a {copper–thiocyanate–dabco} combination, namely, (Hdabco)[Cu2(NCS)3] (1), (H2dabco)[Cu(NCS)3] (2), and [Cu(Hdabco)2(NCS)4]∙2dmso (3), where dabco = 1,4-diazabicyclo[2.2.2]octane were synthesized a...

(This article belongs to the Section Inorganic Chemistry)
  • Review
  • Open Access
114 Citations
11,740 Views
15 Pages

Detection Techniques for Lead Ions in Water: A Review

  • Dan Wu,
  • Yinglu Hu,
  • Huan Cheng and
  • Xingqian Ye

20 April 2023

Lead pollution has increasingly become the focus of environmental pollution, which is a great harm to the ecological environment and human health. Strict control of the emission of lead pollutants and accurate monitoring of lead are very important. T...

(This article belongs to the Special Issue Development of Analytical Methods in Food, Biological and Environmental Samples Determination II)
  • Article
  • Open Access
1 Citations
2,590 Views
10 Pages

20 April 2023

trans-3,4-Dihydroxyselenolane (DHS), a water-soluble cyclic selenide, exhibits selenoenzyme-like unique redox activities through reversible oxidation to the corresponding selenoxide. Previously, we demonstrated that DHS can be applied as an antioxida...

(This article belongs to the Special Issue Advances in Selenium Catalysts and Antioxidants)
  • Article
  • Open Access
15 Citations
3,548 Views
13 Pages

20 April 2023

Bismuth oxide nanoparticles with appropriate surface chemistry exhibit many interesting properties that can be utilized in a variety of applications. This paper describes a new route to the surface modification of bismuth oxide nanoparticles (Bi2O3 N...

(This article belongs to the Special Issue Polysaccharide-Based Biopolymer: Recent Development and Applications)
  • Article
  • Open Access
13 Citations
4,428 Views
20 Pages

20 April 2023

Ticks and tick-borne diseases constitute a substantial hazard to the livestock industry. The rising costs and lack of availability of synthetic chemical acaricides for farmers with limited resources, tick resistance to current acaricides, and residua...

(This article belongs to the Special Issue Density Functional Theory in the Age of Chemical Intelligence)
  • Review
  • Open Access
70 Citations
12,491 Views
20 Pages

The Applications of Electrochemical Immunosensors in the Detection of Disease Biomarkers: A Review

  • Huinan Chen,
  • Jialu Zhang,
  • Rong Huang,
  • Dejia Wang,
  • Dongmei Deng,
  • Qixian Zhang and
  • Liqiang Luo

20 April 2023

Disease-related biomarkers may serve as indicators of human disease. The clinical diagnosis of diseases may largely benefit from timely and accurate detection of biomarkers, which has been the subject of extensive investigations. Due to the specifici...

(This article belongs to the Special Issue Exclusive Papers Collection of Editorial Board Members and Invited Scholars in Applied Chemistry)
  • Article
  • Open Access
22 Citations
5,385 Views
16 Pages

20 April 2023

Improving biomass production with the utilization of low-cost substrate is a crucial approach to overcome the hindrance of high cost in developing large-scale microalgae production. The microalga Coelastrella sp. KKU-P1 was mixotrophically cultivated...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,616 Views
12 Pages

20 April 2023

Polymeric nanoparticles with reactive functional groups are an attractive platform for drug carriers that can be conjugated with drugs through a cleavable covalent linkage. Since the required functional groups vary depending on the drug molecule, the...

(This article belongs to the Special Issue Inventive Biomaterials for Tissue Engineering and Drug Delivery Applications)
  • Article
  • Open Access
7 Citations
4,211 Views
17 Pages

A Chitosan-Based Flocculation Method for Efficient Recovery of High-Purity B-Phycoerythrin from a Low Concentration of Phycobilin in Wastewater

  • Yingye Liang,
  • Luming Deng,
  • Zhenhui Feng,
  • Qianqian Ouyang,
  • Xia Wu,
  • Weiyan Quan,
  • Yuzhen Zhu,
  • Hua Ye,
  • Kefeng Wu and
  • Hui Luo

20 April 2023

Increasing the yield and purity of B-phycoerythrin (B-PE) can improve the economic state of microalgae industrial processing. One method of cost reduction involves the recovery of remaining B-PE from wastewater. In this study, we developed a chitosan...

  • Review
  • Open Access
235 Citations
21,596 Views
26 Pages

The Classification, Molecular Structure and Biological Biosynthesis of Flavonoids, and Their Roles in Biotic and Abiotic Stresses

  • Wei-Bing Zhuang,
  • Yu-Hang Li,
  • Xiao-Chun Shu,
  • Yu-Ting Pu,
  • Xiao-Jing Wang,
  • Tao Wang and
  • Zhong Wang

20 April 2023

With the climate constantly changing, plants suffer more frequently from various abiotic and biotic stresses. However, they have evolved biosynthetic machinery to survive in stressful environmental conditions. Flavonoids are involved in a variety of...

(This article belongs to the Special Issue Polysaccharide-Based Biopolymer: Recent Development and Applications)
  • Article
  • Open Access
16 Citations
4,420 Views
11 Pages

Morphological Electrical and Hardness Characterization of Carbon Nanotube-Reinforced Thermoplastic Polyurethane (TPU) Nanocomposite Plates

  • José Muñoz-Chilito,
  • José A. Lara-Ramos,
  • Lorena Marín,
  • Fiderman Machuca-Martínez,
  • Juan P. Correa-Aguirre,
  • Miguel A. Hidalgo-Salazar,
  • Serafín García-Navarro,
  • Luis Roca-Blay,
  • Luis A. Rodríguez and
  • Jesús E. Diosa
  • + 1 author

20 April 2023

The impacts on the morphological, electrical and hardness properties of thermoplastic polyurethane (TPU) plates using multi-walled carbon nanotubes (MWCNTs) as reinforcing fillers have been investigated, using MWCNT loadings between 1 and 7 wt%. Plat...

(This article belongs to the Special Issue 2D Nanomaterials and Composites for Energy and Environmental Sustainability)
  • Article
  • Open Access
19 Citations
6,155 Views
28 Pages

Development of Activity Rules and Chemical Fragment Design for In Silico Discovery of AChE and BACE1 Dual Inhibitors against Alzheimer’s Disease

  • Le-Quang Bao,
  • Daniel Baecker,
  • Do Thi Mai Dung,
  • Nguyen Phuong Nhung,
  • Nguyen Thi Thuan,
  • Phuong Linh Nguyen,
  • Phan Thi Phuong Dung,
  • Tran Thi Lan Huong,
  • Bakhtiyor Rasulev and
  • Hai Pham-The
  • + 2 authors

20 April 2023

Multi-target drug development has become an attractive strategy in the discovery of drugs to treat of Alzheimer’s disease (AzD). In this study, for the first time, a rule-based machine learning (ML) approach with classification trees (CT) was a...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
9 Citations
3,642 Views
21 Pages

Stabilization of Sunflower Oil with Biologically Active Compounds from Berries

  • Aliona Ghendov-Mosanu,
  • Violina Popovici,
  • Cristina Gabriela Constantinescu (Pop),
  • Olga Deseatnicova,
  • Rodica Siminiuc,
  • Iurie Subotin,
  • Raisa Druta,
  • Adela Pintea,
  • Carmen Socaciu and
  • Rodica Sturza

20 April 2023

Sunflower oil (Helianthus annuus) contains a rich concentration of polyunsaturated fatty acids, which are susceptible to rapid oxidative processes. The aim of this study was to evaluate the stabilizing effect of lipophilic extracts from two types of...

(This article belongs to the Special Issue Natural Products from Plant: From Determination to Application)

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Molecules - ISSN 1420-3049