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Molecules 2018, 23(7), 1520; https://doi.org/10.3390/molecules23071520

Antiproliferative and Antimicrobial Activities of Selected Bryophytes

1
Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary
2
Interdisciplinary Centre for Natural Products, University of Szeged, H-6720 Szeged, Hungary
3
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary
4
Department of Botany and Plant Physiology, Institute of Biology, Eszterházy Károly University, H-3300 Eger, Hungary
5
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Academic Editors: Zhe-Sheng (Jason) Chen and Dong-Hua Yang
Received: 28 May 2018 / Revised: 12 June 2018 / Accepted: 20 June 2018 / Published: 23 June 2018
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
Full-Text   |   PDF [311 KB, uploaded 24 June 2018]

Abstract

One-hundred and sixty-eight aqueous and organic extracts of 42 selected bryophyte species were screened in vitro for antiproliferative activity on a panel of human gynecological cancer cell lines containing HeLa (cervix epithelial adenocarcinoma), A2780 (ovarian carcinoma), and T47D (invasive ductal breast carcinoma) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and for antibacterial activity on 11 strains using the disc-diffusion method. A total of 99 extracts derived from 41 species exerted ≥25% inhibition of proliferation of at least one of the cancer cell lines at 10 μg/mL. In the cases of Brachythecium rutabulum, Encalypta streptocarpa, Climacium dendroides, Neckera besseri, Pleurozium schreberi, and Pseudoleskeella nervosa, more than one extract was active in the antiproliferative assay, whereas the highest activity was observed in the case of Paraleucobryum longifolium. From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts. Only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active Plagiomnium cuspidatum, being active on 8 tested strains. Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus were the most susceptible to the assayed species. This is the first report on the bioactivities of these 14 species. View Full-Text
Keywords: bryophytes; antiproliferative; antibacterial; MTT assay bryophytes; antiproliferative; antibacterial; MTT assay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Vollár, M.; Gyovai, A.; Szűcs, P.; Zupkó, I.; Marschall, M.; Csupor-Löffler, B.; Bérdi, P.; Vecsernyés, A.; Csorba, A.; Liktor-Busa, E.; Urbán, E.; Csupor, D. Antiproliferative and Antimicrobial Activities of Selected Bryophytes. Molecules 2018, 23, 1520.

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