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Molecules 2018, 23(3), 680; https://doi.org/10.3390/molecules23030680

Anticancer Phenolics from Dryopteris fragrans (L.) Schott

1
Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education/Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, China
2
Sino-Russian Joint Laboratory of Bioactive Substance, College of Life Science, Heilongjiang University, Harbin 150080, China
3
Department of Food Science, Tibet Agriculture and Animal Husbandry University, Tibet 860000, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Zhe-Sheng Chen and Dong-Hua Yang
Received: 1 March 2018 / Revised: 16 March 2018 / Accepted: 16 March 2018 / Published: 17 March 2018
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
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Abstract

Cancer is one of the most major diseases that threatens human health and life. The aim of this work was to obtain novel anticancer molecules from D. fragrans, a kind of medicinal plant. The structure of the new compound was identified using spectroscopic data (1H-NMR, 13C-NMR and two dimensions NMR). Its anticancer properties were evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay against four human cells including lung cancer cells (A549), breast cancer cells (MCF-7), gastric cancer cells (SGC7901) and noncancerous human umbilical vein endothelial cells (HUVEC). A new phenylpropanoid—(E)-caffeic acid-9-O-β-d-xylpyranosyl-(1→2)-β-d-glucopyranosyl ester (1), with seven known compounds (28)—was isolated. The IC50 value of compound 1 against MCF-7 cells was 2.65 ± 0.14 µM, and the IC50 values of compound 8 against three cancer cells were below 20 µM. View Full-Text
Keywords: Dryopteris fragrans (L.) Schott; Fragranoside B; anticancer activity Dryopteris fragrans (L.) Schott; Fragranoside B; anticancer activity
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Liu, Z.-D.; Zhao, D.-D.; Jiang, S.; Xue, B.; Zhang, Y.-L.; Yan, X.-F. Anticancer Phenolics from Dryopteris fragrans (L.) Schott. Molecules 2018, 23, 680.

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