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Molecules 2018, 23(3), 680;

Anticancer Phenolics from Dryopteris fragrans (L.) Schott

Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education/Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, China
Sino-Russian Joint Laboratory of Bioactive Substance, College of Life Science, Heilongjiang University, Harbin 150080, China
Department of Food Science, Tibet Agriculture and Animal Husbandry University, Tibet 860000, China
Authors to whom correspondence should be addressed.
Academic Editors: Zhe-Sheng Chen and Dong-Hua Yang
Received: 1 March 2018 / Revised: 16 March 2018 / Accepted: 16 March 2018 / Published: 17 March 2018
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
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Cancer is one of the most major diseases that threatens human health and life. The aim of this work was to obtain novel anticancer molecules from D. fragrans, a kind of medicinal plant. The structure of the new compound was identified using spectroscopic data (1H-NMR, 13C-NMR and two dimensions NMR). Its anticancer properties were evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay against four human cells including lung cancer cells (A549), breast cancer cells (MCF-7), gastric cancer cells (SGC7901) and noncancerous human umbilical vein endothelial cells (HUVEC). A new phenylpropanoid—(E)-caffeic acid-9-O-β-d-xylpyranosyl-(1→2)-β-d-glucopyranosyl ester (1), with seven known compounds (28)—was isolated. The IC50 value of compound 1 against MCF-7 cells was 2.65 ± 0.14 µM, and the IC50 values of compound 8 against three cancer cells were below 20 µM. View Full-Text
Keywords: Dryopteris fragrans (L.) Schott; Fragranoside B; anticancer activity Dryopteris fragrans (L.) Schott; Fragranoside B; anticancer activity

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Liu, Z.-D.; Zhao, D.-D.; Jiang, S.; Xue, B.; Zhang, Y.-L.; Yan, X.-F. Anticancer Phenolics from Dryopteris fragrans (L.) Schott. Molecules 2018, 23, 680.

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