Next Article in Journal
The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response
Next Article in Special Issue
Application of Ammonium Persulfate for Selective Oxidation of Guanines for Nucleic Acid Sequencing
Previous Article in Journal
Specialized Metabolites of the Lichen Vulpicida pinastri Act as Photoprotective Agents
Previous Article in Special Issue
Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(7), 1167; doi:10.3390/molecules22071167

Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea
The authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Zhenjun Yang
Received: 17 June 2017 / Revised: 8 July 2017 / Accepted: 10 July 2017 / Published: 12 July 2017
View Full-Text   |   Download PDF [1057 KB, uploaded 12 July 2017]   |  

Abstract

A series of acyclic selenopurine nucleosides 3af and 4ag were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 µM) and HSV-2 (EC50 = 6.34 µM) activities without cytotoxicity up to 100 µM, while 2,6-diaminopurine derivatives 4eg exhibited significant anti-human cytomegalovirus (HCMV) activity, which is slightly more potent than the guanine derivative 4d, indicating that they might act as prodrugs of seleno-ganciclovir (4d). View Full-Text
Keywords: antiviral; acyclic selenopurine nucleoside; prodrug; anti-herpetic antiviral; acyclic selenopurine nucleoside; prodrug; anti-herpetic
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sahu, P.K.; Umme, T.; Yu, J.; Kim, G.; Qu, S.; Naik, S.D.; Jeong, L.S. Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents. Molecules 2017, 22, 1167.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top