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Molecules 2017, 22(7), 1160; doi:10.3390/molecules22071160

The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response

1
Department of Nutritional Science and Food Management, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
2
Research Group of Bioprocess Engineering, Korea Food Research Institute, Seongnam, Gyeonggi 13539, Korea
3
R&D Center, SKBioland Co. Ltd., 152, Manhae-ro, Danwon-gu, Ansan-si, Gyeonggi-do 15407, Korea
*
Author to whom correspondence should be addressed.
Received: 2 June 2017 / Revised: 29 June 2017 / Accepted: 7 July 2017 / Published: 12 July 2017
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Abstract

Tartary buckwheat (Fagopyrum tataricum) has been established globally as a nutritionally important food item, particularly owing to high levels of bioactive compounds such as rutin. This study investigated the effect of tartary buckwheat extracts (TBEs) on adipogenesis and inflammatory response in 3T3-L1 cells. TBEs inhibited lipid accumulation, triglyceride content, and glycerol-3-phosphate dehydrogenase (GPDH) activity during adipocyte differentiation of 3T3 L1 cells. The mRNA levels of genes involved in fatty acid synthesis, such as peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer binding protein-α (CEBP-α), adipocyte protein 2 (aP2), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoylcoenzyme A desaturase-1 (SCD-1), were suppressed by TBEs. They also reduced the mRNA levels of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and inducible nitric oxide synthase (iNOS). In addition, TBEs were decreased nitric oxide (NO) production. These results suggest that TBEs may inhibit adipogenesis and inflammatory response; therefore, they seem to be beneficial as a food ingredient to prevent obesity-associated inflammation. View Full-Text
Keywords: tartary buckwheat; adipogenesis; inflammatory response; 3T3-L1 adipocytes tartary buckwheat; adipogenesis; inflammatory response; 3T3-L1 adipocytes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lee, M.-S.; Shin, Y.; Jung, S.; Kim, S.-Y.; Jo, Y.-H.; Kim, C.-T.; Yun, M.-K.; Lee, S.-J.; Sohn, J.; Yu, H.-J.; Kim, Y. The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response. Molecules 2017, 22, 1160.

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