Next Article in Journal
Metal-Mediated Addition of N-Nucleophiles to Isocyanides: Mechanistic Aspects
Next Article in Special Issue
The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203
Previous Article in Journal
Phenolics from Mikania micrantha and Their Antioxidant Activity
Previous Article in Special Issue
The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessFeature PaperArticle
Molecules 2017, 22(7), 1145; doi:10.3390/molecules22071145

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Department of Molecular Pharmacology and Experimental Therapeutics, Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Received: 29 June 2017 / Revised: 5 July 2017 / Accepted: 6 July 2017 / Published: 8 July 2017
View Full-Text   |   Download PDF [917 KB, uploaded 8 July 2017]   |  

Abstract

Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the peptide hormone ghrelin and its impact on hunger, obesity, and emotions. Here, we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention. View Full-Text
Keywords: butyrylcholinesterase; adeno-associated virus (AAV)-8; AAV-9; AAV-PHP.B; enzyme expression; ghrelin butyrylcholinesterase; adeno-associated virus (AAV)-8; AAV-9; AAV-PHP.B; enzyme expression; ghrelin
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gao, Y.; Geng, L.; Chen, V.P.; Brimijoin, S. Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice. Molecules 2017, 22, 1145.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top