Phenolics from Mikania micrantha and Their Antioxidant Activity
AbstractA phytochemical study on the aerial parts of Mikania micrantha led to the isolation of two new phenolic compounds, benzyl 5-O-β-d-glucopyranosyl-2,5-dihydroxybenzoate (1) and (7S,8R)-threo-dihydroxydehydrodiconiferyl alcohol 9-acetate (2), together with twelve known compounds, benzyl 2-O-β-d-glucopyranosyl-2,6-dihydroxybenzoate (3), 4-allyl-2,6-dimethoxyphenol glucoside (4), (+)-isolariciresinol (5), icariol A2 (6), 9,10-dihydroxythymol (7), 8,9,10-trihydroxythymol (8), caffeic acid (9), p-coumaric acid (10), ethyl protocatechuate (11), procatechuic aldehyde (12), 4-hydroxybenzoic acid (13), and hydroquinone (14). Their structures were elucidated on the basis of extensive spectroscopic analysis. Except 8 and 9, all the other compounds were isolated from this plant species for the first time. The antioxidant activity of those isolated compounds were evaluated using three different assays. Compounds 1, 2, 3, 9, 10, 13, and 14 demonstrated significant 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) free radical cation scavenging activity ranging from SC50 0.31 to 4.86 µM, which were more potent than l-ascorbic acid (SC50 = 10.48 µM). Compounds 5, 9, 11, and 12 exhibited more potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (SC50 = 16.24–21.67 µM) than l-ascorbic acid (39.48 µM). Moreover, the ferric reducing antioxidant power (FRAP) of compounds 2, 5, 9, and 11 were discovered to be also comparable to or even more potent than l-ascorbic acid. View Full-Text
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Dong, L.-M.; Jia, X.-C.; Luo, Q.-W.; Zhang, Q.; Luo, B.; Liu, W.-B.; Zhang, X.; Xu, Q.-L.; Tan, J.-W. Phenolics from Mikania micrantha and Their Antioxidant Activity. Molecules 2017, 22, 1140.
Dong L-M, Jia X-C, Luo Q-W, Zhang Q, Luo B, Liu W-B, Zhang X, Xu Q-L, Tan J-W. Phenolics from Mikania micrantha and Their Antioxidant Activity. Molecules. 2017; 22(7):1140.Chicago/Turabian Style
Dong, Li-Mei; Jia, Xu-Chao; Luo, Qing-Wen; Zhang, Qiang; Luo, Bi; Liu, Wen-Bin; Zhang, Xu; Xu, Qiao-Lin; Tan, Jian-Wen. 2017. "Phenolics from Mikania micrantha and Their Antioxidant Activity." Molecules 22, no. 7: 1140.
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