Next Article in Journal
Modifications of Porphyrins and Hydroporphyrins for Their Solubilization in Aqueous Media
Next Article in Special Issue
Osteoprotective Effect of Radix Scutellariae in Female Hindlimb-Suspended Sprague-Dawley Rats and the Osteogenic Differentiation Effect of Its Major Constituent
Previous Article in Journal
Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations
Previous Article in Special Issue
Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(6), 978; doi:10.3390/molecules22060978

Hochu-ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome

1
Department of Medical Zoology, College of Medicine, Kyung Hee University, Seoul 130701, Korea
2
Department of Medical Genetics, College of Medicine, Ajou University School of Medicine, Suwon 443721, Korea
3
Bio-Center, Gyeonggido Business and Science Accelerator, Suwon 16229, Korea
4
Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 301747, Korea
5
Department of Medical Science, Chungnam National University School of Medicine, Daejeon 301747, Korea
6
International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
7
Institute of Korea Food and Drug Resource, Seoul 06622, Korea
8
Brain Research Institute, Chungnam National University School of Medicine, Daejeon 301747, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 March 2017 / Revised: 30 May 2017 / Accepted: 7 June 2017 / Published: 13 June 2017
View Full-Text   |   Download PDF [2452 KB, uploaded 13 June 2017]   |  

Abstract

The traditional herbal medicine, Hochu-ekki-to, has been shown to have preventive effects on viral infection and stress. This study aimed to evaluate the clinical effects of Hochu-ekki-to on two stress-related rat models of polycystic ovarian syndrome. Female Sprague-Dawley rats were divided into control and treatment groups, the latter of which were subjected to stress induced by exposure to adrenocorticotropic hormone (ACTH) or cold temperatures. After these stress inductions, rats were orally treated with dissolved Hochu-ekki-to once per day for 7 days. Rats subjected to the two different stressors exhibited upregulation of steroid hormone receptors (in ovaries) and reproductive hormones (in blood), and consequent stimulation of abnormal follicle development accompanied by elevation of Hsp 90 expression (in ovaries). Treatment with Hochu-ekki-to for 7 days after stress induction increased immune functions, reduced the stress-induced activation of Hsp 90, and normalized the levels of the tested steroid hormone receptors and reproductive hormones. Our findings suggest that stress stimulations may promote the activation of Hsp 90 via the dysregulation of steroid hormone receptors and reproductive hormones, but that post-stress treatment with Hochu-ekki-to improves reproductive and immune functions in the ovaries of stressed rats. View Full-Text
Keywords: Hochu-ekki-to; immune modulation; polycystic ovarian syndrome Hochu-ekki-to; immune modulation; polycystic ovarian syndrome
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Park, E.; Choi, C.W.; Kim, S.J.; Kim, Y.-I.; Sin, S.; Chu, J.-P.; Heo, J.Y. Hochu-ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome. Molecules 2017, 22, 978.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top