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Molecules 2017, 22(5), 807; doi:10.3390/molecules22050807

Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa

1
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
2
Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Saudi Arabia
3
Department of Biology, Faculty of Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 15 April 2017 / Revised: 10 May 2017 / Accepted: 10 May 2017 / Published: 15 May 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1178 KB, uploaded 15 May 2017]   |  

Abstract

Chromatographic fractionation of the CH2Cl2/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC50 > 12 mM) using Artemia salina as test organism. Both compounds showed weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, and PC-3 cells, however, they exhibited a relatively potent cytotoxic activity against peripheral blood neutrophils. This can be attributed partly to induction of apoptosis. View Full-Text
Keywords: marine algae; fatty acids; halogenations; spectroscopy; anti-inflammatory marine algae; fatty acids; halogenations; spectroscopy; anti-inflammatory
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Bawakid, N.O.; Alarif, W.M.; Alburae, N.A.; Alorfi, H.S.; Al-Footy, K.O.; Al-Lihaibi, S.S.; Ghandourah, M.A. Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa. Molecules 2017, 22, 807.

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