Next Article in Journal
The Vital Dye CDr10b Labels the Zebrafish Mid-Intestine and Lumen
Next Article in Special Issue
Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood
Previous Article in Journal
Optimization of Conditions for Cyanidin-3-OGlucoside (C3G) Nanoliposome Production by Response Surface Methodology and Cellular Uptake Studies in Caco-2 Cells
Previous Article in Special Issue
Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Molecules 2017, 22(3), 459; doi:10.3390/molecules22030459

Emerging Anti-Mitotic Activities and Other Bioactivities of Sesquiterpene Compounds upon Human Cells

Natural Product and Cancer Cell Laboratories, Department of Biological Sciences, 4401 University Dr, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Nancy D. Turner
Received: 18 January 2017 / Accepted: 2 March 2017 / Published: 13 March 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [3949 KB, uploaded 14 March 2017]   |  

Abstract

We review the bio-activities of natural product sesquiterpenes and present the first description of their effects upon mitosis. This type of biological effect upon cells is unexpected because sesquiterpenes are believed to inactivate proteins through Michael-type additions that cause non-specific cytotoxicity. Yet, certain types of sesquiterpenes can arrest cells in mitosis as measured by cell biology, biochemical and imaging techniques. We have listed the sesquiterpenes that arrest cells in mitosis and analyzed the biological data that support those observations. In view of the biochemical complexity of mitosis, we propose that a subset of sesquiterpenes have a unique chemical structure that can target a precise protein(s) required for mitosis. Since the process of mitotic arrest precedes that of cell death, it is possible that some sesquiterpenes that are currently classified as cytotoxic might also induce a mitotic arrest. Our analysis provides a new perspective of sesquiterpene chemical biology View Full-Text
Keywords: 6-O-Angeloylplenolin; α-methylene-γ-lactone; Asteraceae; checkpoint adaptation; coronopilin; Gaillardia aristata; oxozoapatlin; psilostachyins A and C; sesquiterpene lactone 6-O-Angeloylplenolin; α-methylene-γ-lactone; Asteraceae; checkpoint adaptation; coronopilin; Gaillardia aristata; oxozoapatlin; psilostachyins A and C; sesquiterpene lactone
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bosco, A.; Golsteyn, R.M. Emerging Anti-Mitotic Activities and Other Bioactivities of Sesquiterpene Compounds upon Human Cells. Molecules 2017, 22, 459.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top